Kimura F, Mitsugi N, Arita J, Akema T, Yoshida K
Brain Res. 1987 May 5;410(2):315-22. doi: 10.1016/0006-8993(87)90330-1.
The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian rise of LH secretion in some animals but no appreciable change in PRL secretion. Secretin injection was strikingly effective in increasing circadian rise of LH and PRL secretion. Vasoactive intestinal peptide injection completely abolished the occurrence of circadian rise of LH secretion whereas PHI injection facilitated LH secretion undergoing the circadian rhythm. The results suggest that those peptides act as neurotransmitters or neuromodulators in the preoptic region and are implicated in the regulation of LH and PRL secretion.
在去卵巢并用雌激素预处理的大鼠中，研究了向视前区脑室内注射脑肠肽对促黄体生成素（LH）和催乳素（PRL）分泌的影响。向视前区注射胃泌素或八肽胆囊收缩素，在一些动物中可诱导LH分泌的昼夜节律性升高适度增加，但PRL分泌无明显变化。注射促胰液素对增加LH和PRL分泌的昼夜节律性升高非常有效。注射血管活性肠肽完全消除了LH分泌的昼夜节律性升高，而注射胰高血糖素样肽促进了LH分泌的昼夜节律。结果表明，这些肽在视前区作为神经递质或神经调节剂起作用，并参与LH和PRL分泌的调节。
