Konopacki J, Bland B H, Roth S H
Department of Animal Physiology, University of Lodz, Poland.
Brain Res. 1988 Feb 1;466(2):229-32. doi: 10.1016/0165-3806(88)90048-x.
The development of carbachol-induced EEG theta (theta) activity was studied in the CA1 and dentate regions of hippocampal formation slices obtained from neonatal rats (4, 6, 8, 10, 12 and 14 days of age). When perfused with carbachol (50 microM), 4- and 6-day-old hippocampal slices exhibited only short-lasting irregular activity. The initial appearance of carbachol-induced rhythmic waves were observed in slices obtained from 8-day-old rats. From the time that theta appeared at 8 days of age, a steady increase in amplitude and frequency was noted. This observed in vitro developmental pattern of hippocampal theta-rhythm closely resembles the development of theta activity in in vivo preparations.
研究了新生大鼠（4、6、8、10、12和14日龄）海马结构切片CA1区和齿状区中卡巴胆碱诱导的脑电图θ（theta）活动的发育情况。当用卡巴胆碱（50微摩尔）灌注时，4日龄和6日龄的海马切片仅表现出短暂的不规则活动。在8日龄大鼠的切片中观察到卡巴胆碱诱导的节律性波的最初出现。从8日龄出现θ波开始，振幅和频率稳步增加。这种在体外观察到的海马θ节律的发育模式与体内制剂中θ活动的发育非常相似。
