Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Department of Nephrology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ren Fail. 2021 Dec;43(1):351-361. doi: 10.1080/0886022X.2021.1880939.
The consumption of exogenous antioxidants isolated from herbal extracts has shown beneficial effects on ameliorating dialysis-related complications through debilitating oxidative stress and inflammatory process. Many clinical studies available in public databases have reported the improved consequences of dialysis in patients supplemented with herbal antioxidants. Exploration of such data offers great possibilities for gaining insights into the potential mechanisms and medical implications of herbal antioxidants. In this work, the mechanisms and implications of some famous bioactive substances including silymarin, curcumin, resveratrol, emodin, and quercetin on the consequences of dialysis in chronic kidney disease (CKD) patients were explored. The protective features of silymarin are due to the flavonoid complex silybin. Curcumin is an active element from the root of curcuma longa with extensive beneficial properties, including antioxidant, anti-inflammatory activity, and inhibitory effects on cell apoptosis. Resveratrol can reduce the oxidative stress by neutralization of free radicals. Emodin is known as a natural anthraquinone derivative isolated from Chinese herbs. Finally, quercetin has been reported to exhibit several properties including antioxidant, anti-diabetic, analgesic, antihistaminic, antiviral, cholesterol reducer, and renal hemodynamic modulator. However, potential mechanisms and medical implications of the aforementioned herbal antioxidants seem to be more complicated, that is, more studies are required in this field.
从草药提取物中分离出的外源性抗氧化剂的消耗已显示出通过削弱氧化应激和炎症过程来改善与透析相关的并发症的有益效果。公共数据库中提供的许多临床研究报告了补充草药抗氧化剂的患者透析的改善结果。对这些数据的探索为深入了解草药抗氧化剂的潜在机制和医学意义提供了很大的可能性。在这项工作中，探讨了一些著名生物活性物质（包括水飞蓟素、姜黄素、白藜芦醇、大黄素和槲皮素）对慢性肾脏病（CKD）患者透析结果的机制和影响。水飞蓟素的保护作用归因于类黄酮复合物水飞蓟素。姜黄素是姜黄根中的一种活性成分，具有广泛的有益特性，包括抗氧化、抗炎活性和抑制细胞凋亡的作用。白藜芦醇可以通过中和自由基来减少氧化应激。大黄素是从中药中分离出的一种天然蒽醌衍生物。最后，槲皮素已被报道具有多种特性，包括抗氧化、抗糖尿病、镇痛、抗组胺、抗病毒、降低胆固醇和调节肾脏血流动力学。然而，上述草药抗氧化剂的潜在机制和医学意义似乎更加复杂，即该领域需要更多的研究。
