School of Mental Health, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
School of Mental Health, Wenzhou Medical University, Wenzhou, China.
CNS Neurosci Ther. 2024 Sep;30(9):e14914. doi: 10.1111/cns.14914.
Alzheimer's disease (AD) is a neurodegenerative disorder with limited treatment options. This study aimed to investigate the therapeutic effects of Ginkgo biloba leaf extract (GBE) on AD and explore its potential mechanisms of action.
Key chemical components of GBE, including quercetin, luteolin, and kaempferol, were identified using network pharmacology methods. Bioinformatics analysis revealed their potential roles in AD through modulation of the PI3K/AKT/NF-κB signaling pathway.
Mouse experiments demonstrated that GBE improved cognitive function, enhanced neuronal morphology, and reduced serum inflammatory factors. Additionally, GBE modulated the expression of relevant proteins and mRNA.
GBE shows promise as a potential treatment for AD. Its beneficial effects on cognitive function, neuronal morphology, and inflammation may be attributed to its modulation of the PI3K/AKT/NF-κB signaling pathway. These findings provide experimental evidence for the application of Ginkgo biloba leaf in AD treatment and highlight its potential mechanisms of action.
阿尔茨海默病（AD）是一种神经退行性疾病，治疗选择有限。本研究旨在探讨银杏叶提取物（GBE）对 AD 的治疗作用，并探讨其潜在的作用机制。
采用网络药理学方法鉴定 GBE 的关键化学组成部分，包括槲皮素、木樨草素和山柰酚。通过调节 PI3K/AKT/NF-κB 信号通路，生物信息学分析揭示了它们在 AD 中的潜在作用。
小鼠实验表明，GBE 可改善认知功能、增强神经元形态并降低血清炎症因子。此外，GBE 还调节了相关蛋白和 mRNA 的表达。
GBE 有望成为 AD 的潜在治疗药物。其对认知功能、神经元形态和炎症的有益作用可能归因于对 PI3K/AKT/NF-κB 信号通路的调节。这些发现为银杏叶在 AD 治疗中的应用提供了实验依据，并强调了其潜在的作用机制。
