Department of Gereology, Affiliated Huai'an Hospital of Xuzhou Medical University, ', Huaian, Jiangsu Province, 223002, China.
Department of Clinical Laboratory, Affiliated Huai'an Hospital of Xuzhou Medical University, ', Huaian, Jiangsu Province, 223002, China.
BMC Cardiovasc Disord. 2021 Feb 16;21(1):98. doi: 10.1186/s12872-021-01909-7.
Inflammation is involved in the progression of degenerative valvular heart disease (DVHD). microRNA-222 (miR-222) contributes to inflammation-mediated vascular remodeling, but its involvement in DVHD in relation to atrial fibrillation (AF) is unknown. This study aimed to investigate the changes in miR-222, interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with DVHD complicated with AF.
This was a case control study of patients with DVHD who were hospitalized at the Geriatrics Department of the Affiliated Huai'an Hospital of Xuzhou Medical University between 01/2017 and 08/2018. The participants were grouped according to the presence of AF, and serum miR-222, IL-6, hs-CRP, and NT-proBNP levels were compared.
There were fifty-two participants (28 males) in the DVHD with AF group, aged 60-80 years (73.0 ± 5.9 years). Sixty participants (31 males) were included in the DVHD without AF group, aged 60-80 years (71.9 ± 6.92 years). There were no significant differences in age, sex, body mass index, fasting blood glucose, triglycerides, cholesterol, and blood pressure between the two groups. The serum levels of miRNA-222, IL-6, hs-CRP, and NT-proBNP in DVHD patients were significantly higher in those with AF compared with the non-AF group (all P < 0.05). Correlation analyses revealed that IL-6, hs-CRP, and NT-proBNP levels were positively correlated with miR-222 levels in all patients (IL-6: r = 0.507, P < 0.01; hs-CRP: r = 0.390, P < 0.01; NT-proBNP: r = 0.509, P < 0.01).
Serum miR-222 was independently associated with AF in patients with DVHD.
炎症参与退行性心脏瓣膜病（DVHD）的进展。microRNA-222（miR-222）有助于炎症介导的血管重塑，但它与房颤（AF）相关的 DVHD 之间的关系尚不清楚。本研究旨在探讨 miR-222、白细胞介素（IL）-6、高敏 C 反应蛋白（hs-CRP）和 N 末端脑利钠肽前体（NT-proBNP）在患有 DVHD 合并 AF 的患者中的变化。
这是一项病例对照研究，纳入了 2017 年 1 月至 2018 年 8 月期间在徐州医科大学附属医院老年科住院的 DVHD 患者。根据是否存在 AF 对患者进行分组，并比较血清 miR-222、IL-6、hs-CRP 和 NT-proBNP 水平。
AF 组有 52 名患者（28 名男性），年龄 60-80 岁（73.0±5.9 岁）。无 AF 组有 60 名患者（31 名男性），年龄 60-80 岁（71.9±6.92 岁）。两组在年龄、性别、体重指数、空腹血糖、甘油三酯、胆固醇和血压方面无差异。与非 AF 组相比，DVHD 患者的血清 miR-222、IL-6、hs-CRP 和 NT-proBNP 水平在 AF 组中显著升高（均 P<0.05）。相关性分析显示，在所有患者中，IL-6、hs-CRP 和 NT-proBNP 水平与 miR-222 水平呈正相关（IL-6：r=0.507，P<0.01；hs-CRP：r=0.390，P<0.01；NT-proBNP：r=0.509，P<0.01）。
血清 miR-222 与 DVHD 患者的 AF 独立相关。
