Horjen Anja Wiedswang, Ulimoen Sara Reinvik, Norseth Jon, Svendsen Jesper Hastrup, Smith Pål, Arnesen Harald, Seljeflot Ingebjørg, Tveit Arnljot
a Department of Medical Research , Baerum Hospital, Vestre Viken Hospital Trust , Drammen , Norway.
b Faculty of Medicine , University of Oslo , Oslo, Norway.
Scand J Clin Lab Invest. 2018 Sep;78(5):386-392. doi: 10.1080/00365513.2018.1481224. Epub 2018 Jun 22.
As cardiac troponins emerge as prognostic markers in atrial fibrillation (AF), it is important to identify mechanisms initiating and perpetuating cardiac troponin release, including its relations to other circulating biomarkers, in AF populations. We studied associations between high-sensitivity troponin I (hs-TnI) and markers representing myocardial wall tension, inflammation and haemostasis in persistent AF.
In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion for persistent AF were randomised to receive candesartan or placebo for 3-6 weeks before and 6 months after cardioversion. Associations between baseline levels of hs-TnI and other biomarkers were investigated by bivariate non-parametric correlations (Spearman's correlation coefficient denoted r).
Baseline levels of hs-TnI correlated significantly, although weakly, with interleukin-6 (r = 0.260, p = .003), N-terminal pro-B-type natriuretic peptide (r = 0.251, p = .004), tissue-plasminogen activator antigen (r = 0.233, p = .008), D-dimer (r = 0.220, p = .013), E-selectin (r = 0.207, p = .019), high-sensitivity C-reactive protein (r = 0.202, p = .022) and vascular cell adhesion molecule-1 (r = 0.189, p = .032).
Hs-TnI correlated weakly with biomarkers representing myocardial wall tension, inflammation and haemostasis in persistent AF. The lack of any strong correlation between hs-TnI and the investigated biomarkers is in concert with the idea that hs-TnI release is an independent process parallel to other pathophysiological mechanisms associated with AF.
由于心肌肌钙蛋白已成为心房颤动（AF）的预后标志物，因此确定在AF人群中启动和持续心肌肌钙蛋白释放的机制，包括其与其他循环生物标志物的关系非常重要。我们研究了持续性AF患者中高敏肌钙蛋白I（hs-TnI）与代表心肌壁张力、炎症和止血的标志物之间的关联。
在一项双盲、安慰剂对照研究中，171例因持续性AF接受电复律的患者被随机分为在复律前3 - 6周及复律后6个月接受坎地沙坦或安慰剂治疗。通过双变量非参数相关性（斯皮尔曼相关系数记为r）研究hs-TnI基线水平与其他生物标志物之间的关联。
hs-TnI的基线水平与白细胞介素-6（r = 0.260，p = 0.003）、N末端B型利钠肽原（r = 0.251，p = 0.004）、组织纤溶酶原激活物抗原（r = 0.233，p = 0.008）、D-二聚体（r = 0.220，p = 0.013）、E-选择素（r = 0.207，p = 0.019）、高敏C反应蛋白（r = 0.202，p = 0.022）和血管细胞黏附分子-1（r = 0.189，p = 0.032）显著相关，尽管相关性较弱。
在持续性AF中，hs-TnI与代表心肌壁张力、炎症和止血的生物标志物相关性较弱。hs-TnI与所研究的生物标志物之间缺乏任何强相关性，这与hs-TnI释放是一个独立于与AF相关的其他病理生理机制的过程这一观点一致。
