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生殖支原体和肺炎支原体的唾液酸糖蛋白结合黏附素。

The Sialoglycan Binding Adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae.

机构信息

Instituto de Biología Molecular de Barcelona (IBMB-CSIC), Parc Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain.

Research Unit of Molecular Microbiology (RUMM), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

出版信息

Trends Microbiol. 2021 Jun;29(6):477-481. doi: 10.1016/j.tim.2021.01.011. Epub 2021 Feb 13.

DOI:10.1016/j.tim.2021.01.011
PMID:33593698
Abstract

Mycoplasma genitalium (Mge) and Mycoplasma pneumoniae (Mpn) are two human pathogens associated with urogenital and respiratory tract infections, respectively. The recent elucidation of the tridimensional structure of their major cytoadhesins by X-ray crystallography and cryo-electron microscopy/tomography, has provided important insights regarding the mechanics of infection and evasion of immune surveillance.

摘要

生殖支原体(Mge)和肺炎支原体(Mpn)分别是引起泌尿生殖道和呼吸道感染的两种人类病原体。最近,利用 X 射线晶体学和冷冻电镜/断层扫描技术对其主要细胞黏附素的三维结构进行了阐明,为感染机制和免疫逃避机制提供了重要的见解。

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