Walker B E
Department of Anatomy, Michigan State University, East Lansing 48824.
Cancer Lett. 1988 Apr;39(3):227-31. doi: 10.1016/0304-3835(88)90064-x.
To test the hypothesis that mice exposed prenatally to diethylstilbestrol (DES) develop adenocarcinomas due to sensitivity of vaginal and cervical adenosis to carcinogens, sponges impregnated with methylcholanthrene (MCA) were lodged against the cervix and vaginal fornices of 6-month-old strain CD-1 mice exposed prenatally to DES. Only squamous cell carcinomas developed in these mice, but at a significantly higher rate than in MCA-treated mice not exposed prenatally to DES. An adenosquamous carcinoma and a precursor of adenocarcinoma developed in DES-exposed mice with control sponges.
为了验证产前暴露于己烯雌酚（DES）的小鼠因阴道和宫颈腺病对致癌物敏感而发生腺癌这一假说，将浸有甲基胆蒽（MCA）的海绵放置在产前暴露于DES的6月龄CD-1品系小鼠的宫颈和阴道穹窿处。这些小鼠仅发生了鳞状细胞癌，但其发生率显著高于未产前暴露于DES的MCA处理小鼠。在放置对照海绵的DES暴露小鼠中出现了腺鳞癌和腺癌前体。
