Hiatt R A, Fireman B H
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California 94611.
Cancer Res. 1988 May 15;48(10):2916-8.
We examined the hypothesis that low levels of serum uric acid are associated with elevated cancer risk. A subpopulation (163,830 members) of a large health maintenance organization was followed for a mean of 9.8 years after a multiphasic health checkup at which serum uric acid level was measured. Total cancer incidence as well as site-specific incidence (for lung, colon, and prostate cancer in men and lung, colon, breast, uterine, and cervical cancer in women) was ascertained from hospital discharge records and the Surveillance, Epidemiology and End Results program in the San Francisco-Oakland Bay area. Age-adjusted cancer incidence was not elevated in the lower deciles of serum uric acid level. After adjusting for age, race, education, smoking, alcohol consumption, and body mass, using proportional hazards models, the risk of cancer was not elevated at lower levels of uric acid. Our results suggest that if increased risk of cancer is associated with low serum uric acid, this risk is associated with serum uric levels below those commonly seen in human populations.
我们检验了血清尿酸水平低与癌症风险升高相关这一假设。在一个大型健康维护组织的亚人群（163,830名成员）接受多阶段健康检查并测量血清尿酸水平后，对其进行了平均9.8年的随访。通过医院出院记录以及旧金山 - 奥克兰湾区的监测、流行病学和最终结果计划，确定了总癌症发病率以及特定部位的发病率（男性为肺癌、结肠癌和前列腺癌，女性为肺癌、结肠癌、乳腺癌、子宫癌和宫颈癌）。在血清尿酸水平较低的十分位数中，年龄调整后的癌症发病率并未升高。在使用比例风险模型对年龄、种族、教育程度、吸烟、饮酒和体重进行调整后，尿酸水平较低时癌症风险并未升高。我们的结果表明，如果癌症风险增加与血清尿酸水平低有关，那么这种风险与人群中常见的血清尿酸水平以下的水平有关。
