Huang Junjun, Mi Ningning, Yang Jingli, Zheng Ya, Yuan Jinqiu, Meng Wenbo
Scientific research & Planning Department, The First Hospital of Lanzhou University, Lanzhou, China.
The First Clinical Medical School, Lanzhou University, Lanzhou, China.
Front Oncol. 2024 Dec 23;14:1482814. doi: 10.3389/fonc.2024.1482814. eCollection 2024.
We conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.
We conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and we used a Cox proportional hazards model to analyze the association between SUA levels and the risk of upper gastrointestinal cancer and explore the potential sex-specific relationship.
Of the 475659 participants, 883 eventually developed upper gastrointestinal cancers over a median follow-up period of 6.7 years. We observed that SUA level was positively correlated with the risk of female oral cancer (hazard ratio (95% CI): 2.05(1.03,4.06)) and negatively associated with the risk of esophageal cancer in the general population (hazard ratio (95% CI): 0.65(0.45,0.93)). The risk of gastric cancer in males showed a U-shaped trend, decreasing and then increasing as SUA levels increased (hazard ratio (95% CI): 0.51(0.32,0.81)). The risk of small intestine cancer in females showed a trend of increasing and then decreasing with increasing SUA levels (hazard ratio (95% CI): 3.34(1.10,10.13)). Interaction analysis indicated that various factors, such as age, sex, smoking and drinking status, family history of cancer and BMI might play an important role in the relationship between SUA and cancer.
SUA levels are positively associated with the risk of oral cancer risk in females and negatively associated with the risk of esophageal cancer in the general population. Both low and high SUA levels were associated with increased risk of gastric cancer, supporting a U-shaped association.
我们开展本研究以调查血清尿酸（SUA）水平与上消化道癌症风险之间的关系。
我们对英国生物银行中475659名无癌症参与者进行了一项前瞻性队列研究。所有受试者被分为四分位数，我们使用Cox比例风险模型分析SUA水平与上消化道癌症风险之间的关联，并探讨潜在的性别特异性关系。
在475659名参与者中，883人在中位随访期6.7年期间最终患上了上消化道癌症。我们观察到，SUA水平与女性口腔癌风险呈正相关（风险比（95%置信区间）：2.05（1.03，4.06）），与普通人群食管癌风险呈负相关（风险比（95%置信区间）：0.65（0.45，0.93））。男性胃癌风险呈U形趋势，随着SUA水平升高先降低后升高（风险比（95%置信区间）：0.51（0.32，0.81））。女性小肠癌风险随着SUA水平升高呈先升高后降低的趋势（风险比（95%置信区间）：3.34（1.10，10.13））。交互分析表明，年龄、性别、吸烟和饮酒状况、癌症家族史和体重指数等各种因素可能在SUA与癌症的关系中起重要作用。
SUA水平与女性口腔癌风险呈正相关，与普通人群食管癌风险呈负相关。低SUA水平和高SUA水平均与胃癌风险增加相关支持U形关联。
