Kolonel L N, Yoshizawa C, Nomura A M, Stemmermann G N
Cancer Research Center, University of Hawaii, Honolulu 96813.
Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):225-8.
Uric acid is a potent antioxidant and thus might protect against cancer. To test this hypothesis, we examined the relationship of serum uric acid to subsequent cancer incidence in a cohort of Japanese men in Hawaii. The study population consisted of 7889 men identified in the years 1965-1968 and followed by active hospital surveillance through November 1991. Cancer risk by serum uric acid level was analyzed using Cox proportional hazards regression with adjustment for age and, where indicated, smoking, alcohol use, and body mass index. No significant associations were seen for total cancer (1544 cases), or for cancers of the stomach (214), colon (272), rectum (105), lung (223), bladder (89), or hematopoietic system (77). For prostate cancer (293 cases), a positive association was found (relative risk for highest versus lowest quartile of serum uric acid = 1.5; 95% confidence interval 1.1-2.1; p for trend = 0.04). When the interval from examination to diagnosis was considered, this association was strongest for cases diagnosed in the first 10 years, was attenuated after 15 years, and disappeared completely after 20 years. The findings from this study do not support the hypothesis that uric acid protects against cancer occurrence.
尿酸是一种强效抗氧化剂，因此可能预防癌症。为验证这一假设，我们在夏威夷的一群日本男性中研究了血清尿酸水平与后续癌症发病率之间的关系。研究对象包括1965年至1968年间确定的7889名男性，并通过积极的医院监测随访至1991年11月。使用Cox比例风险回归分析血清尿酸水平与癌症风险的关系，并对年龄以及必要时对吸烟、饮酒和体重指数进行调整。在总癌症（1544例）、胃癌（214例）、结肠癌（272例）、直肠癌（105例）、肺癌（223例）、膀胱癌（89例）或造血系统癌症（77例）方面均未发现显著关联。对于前列腺癌（293例），发现存在正相关（血清尿酸最高四分位数与最低四分位数相比的相对风险 = 1.5；95%置信区间1.1 - 2.1；趋势p值 = 0.04）。当考虑从检查到诊断的时间间隔时，这种关联在诊断后10年内最为明显，15年后减弱，20年后完全消失。本研究结果不支持尿酸预防癌症发生这一假设。
