一类水溶性 Fe(III)配合物作为 T2 加权 MRI 对比剂。
A class of water-soluble Fe(III) coordination complexes as -weighted MRI contrast agents.
机构信息
Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
出版信息
J Mater Chem B. 2021 Feb 25;9(7):1787-1791. doi: 10.1039/d0tb02716b.
Iron-based coordination complexes are showing increasing potential to be alternatives for T1-weighted magnetic resonance imaging (MRI) and contribute to the safety of gadolinium-based compounds. In this work, three water-soluble iron-based complexes constructed using catechol ligands exhibiting T1-weighted MRI contrast behavior are described. The longitudinal relaxivity (r1) increase from 0.88 to 1.43 mM-1 s-1 mainly depends on the sizes and the number of water molecules in the second and outer spheres around the discrete complexes.
基于铁的配位化合物在 T1 加权磁共振成像（MRI）方面显示出越来越大的应用潜力，并且有助于提高基于钆化合物的安全性。在这项工作中，描述了三种使用儿茶酚配体构建的具有 T1 加权 MRI 对比行为的水溶性铁基配合物。纵向弛豫率（r1）从 0.88 增加到 1.43 mM-1 s-1，主要取决于离散配合物中第二和外部球体中水的大小和数量。
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