Dermatology Resident, Dermatology Department, American University of Beirut, Beirut, Lebanon.
Professor, Dermatology Department, American University of Beirut, Beirut, Lebanon.
Am J Dermatopathol. 2021 Mar 1;43(3):163-173. doi: 10.1097/DAD.0000000000001769.
Osteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management.
破骨细胞样巨细胞（OLGCs）因其丰富的细胞质和发达的细胞器而类似于破骨细胞。OLGCs 是腱鞘巨细胞瘤和软组织巨细胞瘤的特征性特征，但也在许多其他皮肤疾病中有所描述。OLGCs 的存在的诊断和预后意义尚不清楚。在这里，我们总结了可能出现这些细胞的临床实体，以避免组织学重叠，影响诊断和治疗。
