不同的[具体基因名称1]和[具体基因名称2]基因表达水平通过[具体机制]导致复发性外阴阴道念珠菌病。 （注：原文中部分关键信息缺失，需补充完整才能准确翻译）
Different expression levels of and genes contribute to recurrent vulvovaginal candidiasis by .
作者信息
Bonfim-Mendonça Patrícia de S, Tobaldini-Valério Flávia K, Capoci Isis Rg, Faria Daniella R, Sakita Karina M, Arita Glaucia S, Negri Melyssa, Kioshima Érika S, Svidzinski Terezinha Ie
机构信息
Departamento de Análises Clínicas e Biomedicina. Laboratório Micologia Médica. Universidade Estadual de Maringá. Maringá, Paraná, CEP: 87020-900, Brazil.
Programa de Pós-graduação em Biociências e Fisiopatologia. Universidade Estadual de Maringá. Maringá, Paraná, CEP: 87020-900, Brazil.
出版信息
Future Microbiol. 2021 Mar;16:211-219. doi: 10.2217/fmb-2020-0059. Epub 2021 Feb 17.
To study the behavior of in women with vulvovaginal candidiasis (VVC), recurrent VVC (RVVC) and asymptomatic (AS), regarding adhesion on HeLa cells and their ability to express secreted aspartic proteinases () genes, agglutinin-like sequence () genes and . The adhesion of to HeLa cells was evaluated by colony-forming units, and the expressed genes were evaluated by qRT-PCR. AS and VVC isolates showed greater ability to adhere HeLa cells when compared with RVVC isolate. Nevertheless, RVVC isolate exhibited upregulation of a large number of genes of and gene families and gene. The results demonstrated that RVVC isolate expressed significantly important genes for invasion and yeast-host interactions.
为研究白色念珠菌在患有外阴阴道念珠菌病（VVC）、复发性外阴阴道念珠菌病（RVVC）和无症状感染（AS）的女性中的行为，涉及对HeLa细胞的黏附及其表达分泌天冬氨酸蛋白酶（Saps）基因、凝集素样序列（Als）基因和其他基因的能力。通过菌落形成单位评估白色念珠菌对HeLa细胞的黏附，并通过qRT-PCR评估表达的基因。与RVVC分离株相比，AS和VVC分离株显示出更强的黏附HeLa细胞的能力。然而，RVVC分离株表现出大量Saps基因家族、Als基因和其他基因的上调。结果表明，RVVC分离株表达了对侵袭和酵母与宿主相互作用至关重要的基因。
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