Persano Francesca, Batasheva Svetlana, Fakhrullina Gölnur, Gigli Giuseppe, Leporatti Stefano, Fakhrullin Rawil
University of Salento, Department of Mathematics and Physics, Via Per Arnesano 73100, Lecce, Italy.
J Mater Chem B. 2021 Mar 28;9(12):2756-2784. doi: 10.1039/d0tb02957b. Epub 2021 Feb 17.
Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery. This review aims at overviewing recent developments of inorganic nanoparticles (like porous or mesoporous silica particles) and different nano-clay materials (like montmorillonite, laponites or halloysite nanotubes) employed for overcoming the blood brain barrier (BBB) in the treatment and therapy of major brain diseases such as Alzheimer's, Parkinson's, glioma or amyotrophic lateral sclerosis. Recent strategies of crossing the BBB through invasive and not invasive administration routes by using different types of nanoparticles compared to nano-clays and inorganic particles are overviewed.
无机材料，特别是纳米粘土和二氧化硅纳米颗粒，因其具有多种特性且可调节，而备受关注，这使其成为广泛生物医学应用（如药物递送）的理想候选材料。本综述旨在概述无机纳米颗粒（如多孔或介孔二氧化硅颗粒）和不同纳米粘土材料（如蒙脱石、锂皂石或埃洛石纳米管）的最新进展，这些材料用于在治疗诸如阿尔茨海默病、帕金森病、神经胶质瘤或肌萎缩侧索硬化症等主要脑部疾病时突破血脑屏障（BBB）。与纳米粘土和无机颗粒相比，本文还概述了通过使用不同类型的纳米颗粒，经侵入性和非侵入性给药途径穿越血脑屏障的最新策略。
