Baeza-Velasco Carolina, Hamonet Claude, Montalescot Lucile, Courtet Philippe
Arch Suicide Res. 2022 Jul-Sep;26(3):1314-1326. doi: 10.1080/13811118.2021.1885538. Epub 2021 Feb 17.
Hypermobile Ehlers-Danlos syndrome (hEDS) is the most frequent heritable disorder of the connective tissue. This is characterized by a generalized fragility of tissues leading to chronic pain, disability and high levels of psychological distress. Suicidal behaviors in those affected are not uncommon but they have not been well studied. We aimed to explore aspects of suicidality and related factors in a group of patients with hEDS.
Thirty-five women with hEDS were included in this cross-sectional study. They were assessed with the Mini-International Neuropsychiatric Interview for Axis 1 DSM-IV mental disorders and suicidality. They also responded to self-questionnaires assessing health (pain, BMI, and diagnosis delay) and psychosocial variables (social support, physical functioning, coping strategies, personality disturbances, and resilience).
Eleven patients (31.4%) had attempted suicide in the past. Fifteen patients (42.9%) had some degree of suicide risk at the time of evaluation, mainly mild risk (60%). Compared with patients without a history of suicide attempt, those who had attempted suicide were younger, scored higher on personality disturbances, especially on depressive, avoidant, antisocial, and borderline trait subscores, and had an increased prevalence of lifetime major depression, mania/hypomanic episodes, and anxiety disorders ( < .05). Binary logistic regression showed that personality disturbances and anxiety disorders increase the probability of belonging to the attempters group.
Consistent with previous reports, these data highlight the high frequency of suicidal behaviors in hEDS patients as well as the importance to explore psychopathology in those affected in order to identify vulnerable individuals and provide specific support.HIGHLIGHTSAttempted suicide in patients with hEDS is not uncommon.Age and the presence of psychopathology are associated with suicide attempt in hEDS patients.Personality disturbances and lifetime anxiety disorders predicted suicide attempted in this sample.
关节过度活动型埃勒斯-当洛综合征（hEDS）是最常见的遗传性结缔组织疾病。其特征是组织普遍脆弱，导致慢性疼痛、残疾和高度心理困扰。该病患者出现自杀行为并不罕见，但尚未得到充分研究。我们旨在探讨一组hEDS患者的自杀倾向及相关因素。
本横断面研究纳入了35名患有hEDS的女性。她们接受了针对轴I DSM-IV精神障碍和自杀倾向的迷你国际神经精神访谈评估。她们还回答了评估健康状况（疼痛、体重指数和诊断延迟）以及心理社会变量（社会支持、身体功能、应对策略、人格障碍和心理韧性）的自填问卷。
11名患者（31.4%）过去曾有过自杀未遂经历。15名患者（42.9%）在评估时存在一定程度的自杀风险，主要为轻度风险（60%）。与无自杀未遂史的患者相比，有自杀未遂经历的患者更年轻，人格障碍得分更高，尤其是在抑郁、回避、反社会和边缘特质子量表上得分更高，且终生患重度抑郁症、躁狂/轻躁狂发作和焦虑症的患病率更高（P<0.05）。二元逻辑回归显示，人格障碍和焦虑症会增加属于自杀未遂组的概率。
与之前的报告一致，这些数据凸显了hEDS患者中自杀行为的高发生率，以及探索患者心理病理学以识别易患个体并提供特定支持的重要性。
hEDS患者自杀未遂并不罕见。
年龄和心理病理学的存在与hEDS患者的自杀未遂有关。
人格障碍和终生焦虑症可预测本样本中的自杀未遂情况。
