Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4030030, China; Institute for Brain Research, Wuhan Center of Brain Science, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Pathophysiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Institute for Brain Research, Wuhan Center of Brain Science, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Pathophysiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Cell Rep. 2021 Feb 16;34(7):108741. doi: 10.1016/j.celrep.2021.108741.
Mossy cells (MCs) are a unique group of excitatory neurons in the hippocampus, a brain region important for emotion, learning, and memory. Due to the lack of a reliable method to isolate MCs from other cell types, how MCs integrate neural information and convey it to their synaptic targets for engaging a specific function are still unknown. Here, we report that MCs control the efficacy of spatial memory retrieval by synapsing directly onto local somatostatin-expressing (SST) cells. MC-SST synaptic transmission undergoes long-term potentiation (LTP), requiring Gria2-lacking Ca-permeable anti-α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (CaAR). A long noncoding RNA (Gria2I) is associated with Gria2 transcriptional repressors in SST cells. Silencing Gria2I induces Gria2 transcription, blocks LTP of MCs-SST synaptic transmission, and reduces the efficacy of memory retrieval. Thus, MCs directly and functionally innervate local SST neurons, and this innervation controls the efficacy of spatial memory retrieval by Gria2I inhibition of Gria2 transcription.
苔状细胞（MCs）是海马体中一种独特的兴奋性神经元群体，海马体是情感、学习和记忆的重要区域。由于缺乏一种可靠的方法将 MCs 从其他细胞类型中分离出来，因此 MCs 如何整合神经信息并将其传递到其突触靶标以实现特定功能仍然未知。在这里，我们报告 MCs 通过直接与局部表达生长抑素的（SST）细胞形成突触来控制空间记忆检索的功效。MC-SST 突触传递经历长时程增强（LTP），需要缺乏 Gria2 的钙通透性非 NMDA 受体（CaAR）。一种长非编码 RNA（Gria2I）与 SST 细胞中的 Gria2 转录抑制剂相关。沉默 Gria2I 诱导 Gria2 转录，阻断 MC-SST 突触传递的 LTP，并降低记忆检索的功效。因此，MCs 直接且功能上支配局部 SST 神经元，并且这种支配通过 Gria2I 抑制 Gria2 转录来控制空间记忆检索的功效。
