School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Grade Three Laboratory of Traditional Chinese Medicine Preparation of the National Administration of Traditional Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
Int J Biol Macromol. 2021 Jul 31;183:119-131. doi: 10.1016/j.ijbiomac.2021.04.139. Epub 2021 Apr 24.
Hedyotis diffusa polysaccharides, as the main component and an important bioactive substance of Hedyotis diffusa, are effective immunomodulators with various pharmacological activities, including antitumour, anti-inflammatory, antioxidant, anti-fatigue and immunity-enhancing activities. The total polysaccharides extracted from Hedyotis diffusa and Scutellaria barbata have great effects in treating liver cancer, gastric cancer, rectal cancer, glioma and nasopharyngeal carcinoma. Moreover, different materials and extraction methods result in differences in the structure and bioactivity of Hedyotis diffusa polysaccharides. Therefore, this paper summarizes the isolation, purification, structural characteristics, pharmacological activities, and combined action of Hedyotis diffusa polysaccharides to provide a reference for further study.
白花蛇舌草多糖作为白花蛇舌草的主要成分和重要生物活性物质，是一种有效的免疫调节剂，具有多种药理活性，包括抗肿瘤、抗炎、抗氧化、抗疲劳和增强免疫力活性。从白花蛇舌草和半枝莲中提取的总多糖对肝癌、胃癌、直肠癌、脑胶质瘤和鼻咽癌有很大的治疗作用。此外，不同的材料和提取方法导致白花蛇舌草多糖的结构和生物活性存在差异。因此，本文总结了白花蛇舌草多糖的分离、纯化、结构特征、药理活性以及与其他药物的联合作用，为进一步的研究提供参考。
