Salleh H M, Chong S-L, Othman R, Hazni H, Ahmad K, Mohd Yusof M Y Z, Fauzi N W, Wahab H A, Liew S Y, Awang K
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Centre for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia.
Trop Biomed. 2019 Jun 1;36(2):357-366.
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC value of 0.30 ± 0.16 µg/mL.
登革热是包括马来西亚在内的全球主要健康问题之一。它由节肢动物传播的黄病毒引起，通过感染四种登革病毒血清型（DENV-1、DENV-2、DENV-3或DENV-4）之一的埃及伊蚊或白纹伊蚊叮咬传播。在本研究中，对各种马来西亚药用植物的筛选试验表明，无患子、龙脑香、石榴、枣和红球姜的提取物对NS2B-NS3丝氨酸蛋白酶具有强大的抑制活性。龙脑香的甲醇提取物在浓度为200µg/mL时显示出99.70%的抑制率，IC值为0.30±0.16µg/mL。
