Department of Pediatrics and Child Health, Livingstone Central hospital, Livingstone, Zambia.
Department of Pharmacy, Livingstone Central Hospital, Livingstone, Zambia.
Pan Afr Med J. 2020 Nov 26;37:276. doi: 10.11604/pamj.2020.37.276.21850. eCollection 2020.
Nicolau syndrome (NS) is a rare injection site reaction, following intramuscular injection of drugs characterized by severe pain, skin discoloration and varying level of tissue necrosis. The case outcomes vary from severe pain, atrophic ulcers to sepsis and limb amputation. We describe a case of the five-year-old girl with diagnosis of NS after intramuscular benzathine penicillin injection. The case was complicated with above the knee amputation of lower limb. This case report intends to remind clinicians that such rare cases should always be thought of in all patients receiving whatsoever drug via intramuscular injections.
尼科劳综合征（NS）是一种罕见的肌肉注射药物后发生的注射部位反应，其特征为严重疼痛、皮肤变色和不同程度的组织坏死。其病例结局从严重疼痛、萎缩性溃疡到脓毒症和肢体截肢不等。我们描述了一例五岁女孩在肌内注射苄星青霉素后诊断为 NS 的病例。该病例并发了下肢膝关节以上的截肢。本病例报告旨在提醒临床医生，对于所有接受肌内注射任何药物的患者，都应考虑到这种罕见病例。
