Ozlu Emin, Baykan Aysegul, Ertas Ragıp, Ulas Yılmaz, Ozyurt Kemal, Avcı Atıl, Baykan Halit
Department of Dermatology, School of Medicine, Duzce University, Duzce, 81620, Turkey.
Department of Dermatology, Kayseri Tekden Hospital, Kayseri, 38000, Turkey.
F1000Res. 2017 Jun 12;6:867. doi: 10.12688/f1000research.11705.1. eCollection 2017.
Nicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Etofenamate is a non-steroidal anti-inflammatory drug and a non-selective cyclooxygenase inhibitor. Cutaneous adverse findings caused by etofenamate are uncommon. Herein, we present a case with diagnosis of Nicolau syndrome due to etofenamate injection, which is a rare occurrence.
尼科劳综合征，也称为药物性皮肤栓塞，是一种罕见的并发症，其特征为注射药物后发生组织坏死。确切的发病机制尚不确定，但有几种假说，包括终末动脉的直接损伤和药物的细胞毒性作用。注射后即刻出现的严重疼痛以及皮肤呈网状色素沉着的紫色变色是该综合征的特征。诊断主要依靠临床，且该疾病尚无标准治疗方法。依托芬那酯是一种非甾体抗炎药和非选择性环氧化酶抑制剂。依托芬那酯引起的皮肤不良反应并不常见。在此，我们报告一例因注射依托芬那酯而诊断为尼科劳综合征的病例，这是一种罕见情况。
