*Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
†Institute of Medicine of Chung Shun Medical University, Taichung, Taiwan.
Am J Chin Med. 2019;47(5):1171-1191. doi: 10.1142/S0192415X19500605. Epub 2019 Jul 17.
Melanoma, which has a high metastatic capacity and death rate, is a common skin cancer in Western countries. The purpose of this study was to address whether (JCo) extract is effective in the suppression of melanoma and to elucidate the anticancer mechanisms involved and . The antitumor capacities of JCo extract on tumor suppression and toxicity were evaluated and the results demonstrated that the tumor burden was reduced via mediation of cell cycle, reduction of autocrine signaling, and induction of apoptosis. Moreover, JCo extract significantly prolonged the survival rate of the test subjects with only low pathological and physiological toxicity. Additionally, JCo extract also reduced cancer stem cell-related angiogenic and metastatic proteins in the process of tumor elimination. Based on these results, this study suggests that JCo extract suppresses tumor growth and induces apoptosis, and JCo extract may be useful for the prevention of melanoma tumorigenesis.
黑色素瘤具有较高的转移能力和死亡率，是西方国家常见的皮肤癌。本研究旨在探讨 (JCo) 提取物是否能有效抑制黑色素瘤，并阐明其涉及的抗癌机制。评估了 JCo 提取物对肿瘤抑制和毒性的抗肿瘤能力，结果表明通过细胞周期调节、减少自分泌信号和诱导细胞凋亡来减轻肿瘤负担。此外，JCo 提取物还能显著提高受试对象的存活率，同时仅有低病理和生理毒性。此外，JCo 提取物在消除肿瘤的过程中还降低了与癌症干细胞相关的血管生成和转移蛋白。基于这些结果，本研究表明 JCo 提取物抑制肿瘤生长并诱导细胞凋亡，JCo 提取物可能有助于预防黑色素瘤的发生。
