Samadi-Noshahr Zahra, Hadjzadeh Mousa-Al-Reza, Moradi-Marjaneh Reyhaneh, Khajavi-Rad Abolfazl
Student Research Committee Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Department of Physiology Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Food Sci Nutr. 2020 Dec 30;9(2):1121-1131. doi: 10.1002/fsn3.2090. eCollection 2021 Feb.
Hypoglycemic, anti-inflammatory, and antioxidant activities of fennel have been recorded in numerous investigations. The study aimed to evaluate the protective effects of fennel or its active component -Anethole (TA) on streptozotocin-induced liver injury in rats. Rats were injected with a single dose of STZ (65 mg/kg) and treated with fennel (200 and 400 mg/kg), TA (80 mg/kg), or metformin (300 mg/kg) for 35 days. Serum lipid profile and liver enzyme activity (aminotransferases), oxidative stress markers, and the degree of fibrosis in the liver tissue were assessed. Both fennel and TA decreased blood glucose levels, reduced liver enzyme activity, food, and water intake, and intensity of weight loss, reduced serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and increased high-density lipoprotein cholesterol (HDL-c). Additionally, fennel and TA significantly reduced MDA concentration while increased CAT activity and thiol content and reduced the degree of injury and fibrosis in the liver of diabetic rats. Our results suggest that fennel seed extract and its active compound TA are able to protect the liver against diabetes-induced hepatic injury in rats, probably via hypoglycemic and antioxidant effects.
在众多研究中已记录了茴香的降血糖、抗炎和抗氧化活性。本研究旨在评估茴香或其活性成分——反式茴香脑（TA）对链脲佐菌素诱导的大鼠肝损伤的保护作用。给大鼠注射单剂量的链脲佐菌素（65 mg/kg），并用茴香（200和400 mg/kg）、TA（80 mg/kg）或二甲双胍（300 mg/kg）治疗35天。评估血清脂质谱和肝酶活性（转氨酶）、氧化应激标志物以及肝组织中的纤维化程度。茴香和TA均降低了血糖水平，降低了肝酶活性、食物和水摄入量以及体重减轻的强度，降低了血清甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-c），并提高了高密度脂蛋白胆固醇（HDL-c）。此外，茴香和TA显著降低了丙二醛（MDA）浓度，同时提高了过氧化氢酶（CAT）活性和硫醇含量，并减轻了糖尿病大鼠肝脏的损伤程度和纤维化程度。我们的结果表明，茴香籽提取物及其活性化合物TA可能通过降血糖和抗氧化作用，能够保护大鼠肝脏免受糖尿病诱导的肝损伤。
