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Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).随机试验伊立替康和西妥昔单抗与或无维莫非尼在 BRAF 突变转移性结直肠癌(SWOG S1406)。
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Encorafenib, Binimetinib, and Cetuximab in V600E-Mutated Colorectal Cancer.encorafenib、binimetinib 和西妥昔单抗治疗 V600E 突变型结直肠癌。
N Engl J Med. 2019 Oct 24;381(17):1632-1643. doi: 10.1056/NEJMoa1908075. Epub 2019 Sep 30.
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Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial.口服冷冻疗法在奥沙利铂输注期间预防口腔热痛觉过敏的疗效:一项随机试验。
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Cancer statistics, 2019.癌症统计数据,2019 年。
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Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.纳武利尤单抗治疗转移性DNA错配修复缺陷或微卫星高度不稳定结直肠癌患者(CheckMate 142):一项开放标签、多中心、2期研究。
Lancet Oncol. 2017 Sep;18(9):1182-1191. doi: 10.1016/S1470-2045(17)30422-9. Epub 2017 Jul 19.
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Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial.一线化疗联合西妥昔单抗或贝伐单抗对KRAS野生型晚期或转移性结直肠癌患者总生存期的影响:一项随机临床试验
JAMA. 2017 Jun 20;317(23):2392-2401. doi: 10.1001/jama.2017.7105.

改善转移性结直肠癌患者的治疗结局:挑战与策略

Improving Outcomes for Patients With Metastatic Colorectal Cancer: Challenges and Strategies.

作者信息

Swanson Leslie A, Boyle Kathleen

机构信息

University of Washington/Seattle Cancer Care Alliance.

Dana-Farber Cancer Institute, Boston, Massachusetts.

出版信息

J Adv Pract Oncol. 2020 Apr;11(3):291-296. doi: 10.6004/jadpro.2020.11.3.15. Epub 2020 Apr 1.

DOI:10.6004/jadpro.2020.11.3.15
PMID:33598328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7857319/
Abstract

At JADPRO Live 2019, Leslie A. Swanson, ARNP, and Kathleen Boyle, PA-C, reviewed guideline-concordant molecular testing and therapy in patients with metastatic colorectal cancer (mCRC), the clinical significance of emerging data for existing and novel agents used to treat mCRC, and the management of adverse events associated with mCRC therapies.

摘要

在2019年JADPRO直播活动中,高级注册护士莱斯利·A·斯旺森和执业助理医师凯瑟琳·博伊尔回顾了转移性结直肠癌(mCRC)患者的指南一致性分子检测与治疗、用于治疗mCRC的现有及新型药物的新数据的临床意义,以及与mCRC治疗相关的不良事件的管理。