对映选择性α-羰基化芳基化反应用于简便构建手性螺环β,β'-二酮
Enantioselective α-Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β'-Diketones.
作者信息
Wu Ting, Zhou Qinghai, Tang Wenjun
机构信息
State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Ling Ling Rd, Shanghai, 200032, China.
College of Chemistry and Materials Science, Shanghai Normal University, 106 Guilin Road, Shanghai, 200233, China.
出版信息
Angew Chem Int Ed Engl. 2021 Apr 26;60(18):9978-9983. doi: 10.1002/anie.202101668. Epub 2021 Mar 17.
We herein describe the first enantioselective α-carbonylative arylation, providing a diverse set of chiral spiro β,β'-diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway.
我们在此描述了首例对映选择性α-羰基化芳基化反应，该反应能以高收率和良好至优异的对映选择性提供多种具有不同环大小和官能团的手性螺环β,β'-二酮。计算结果表明该转化过程是通过还原消除而非亲核加成途径进行的。
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