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老年人中的抑郁与炎症升高:2003 年 SARS 疫情八年后的情况。

Depression and Elevated Inflammation Among Chinese Older Adults: Eight Years After the 2003 SARS Epidemic.

机构信息

Population Research Institute, The Pennsylvania State University, University Park, USA.

Department of Gerontology, John W. McCormack Graduate School of Policy and Global Studies, University of Massachusetts Boston, USA.

出版信息

Gerontologist. 2021 Feb 23;61(2):273-283. doi: 10.1093/geront/gnaa219.

Abstract

BACKGROUND AND OBJECTIVES

This study examined associations between exposure to the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic and Chinese older adults' depression and inflammation 8 years after the crisis. Further, this study investigated the buffering effects of perceived social support and social participation.

RESEARCH DESIGN AND METHODS

Data were drawn from the 2011 China Health and Retirement Longitudinal Survey, including N = 4,341 Chinese adults aged 60 years and older. For the survey, local officials identified whether the 2003 SARS outbreak was one of the major disasters in the history of their communities. Depression was assessed by the Center for Epidemiological Studies-Depression scale and inflammation was measured by C-reactive protein (CRP) collected from participants via venous blood draws.

RESULTS

Results from multilevel logistic regression models revealed that Chinese older adults living in communities exposed to SARS were more likely to have elevated CRP compared to those not living in such communities. Moreover, community SARS exposure was associated with greater risks of depression for Chinese older adults who had no perceived social support. Among Chinese older adults who had low levels of social participation, community SARS exposure was more strongly related to elevated CRP.

DISCUSSION AND IMPLICATIONS

Findings suggest community-level exposure to the SARS epidemic had enduring consequences for Chinese older adults' health. However, active social participation and supportive social ties provided important resources that may buffer against negative effects of exposure to the SARS epidemic.

摘要

背景与目的

本研究旨在探讨 2003 年严重急性呼吸综合征(SARS)疫情暴露与危机 8 年后中国老年人群抑郁和炎症之间的关系。此外,本研究还探讨了感知社会支持和社会参与的缓冲作用。

研究设计与方法

数据来自 2011 年中国健康与退休纵向调查,包括 4341 名年龄在 60 岁及以上的中国成年人。在调查中,地方官员确定 2003 年 SARS 疫情是否是他们社区历史上的主要灾害之一。抑郁程度通过流行病学研究中心抑郁量表进行评估,炎症通过静脉采血从参与者处采集 C 反应蛋白(CRP)进行测量。

结果

多水平逻辑回归模型的结果表明,与未居住在 SARS 疫情社区的老年人相比,居住在暴露于 SARS 疫情社区的中国老年人的 CRP 水平更高。此外,对于没有感知到社会支持的中国老年人来说,社区 SARS 暴露与更高的抑郁风险有关。对于社会参与度较低的中国老年人来说,社区 SARS 暴露与 CRP 升高的关系更为密切。

讨论与意义

研究结果表明,社区层面暴露于 SARS 疫情对中国老年人群的健康有持久的影响。然而,积极的社会参与和支持性的社会关系提供了重要的资源,可以缓冲 SARS 疫情暴露的负面影响。

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