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Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies.

作者信息

Dong Hu, Liu Pan, Bai Manyuan, Wang Kang, Feng Rui, Zhu Dandan, Sun Yao, Mu Suyu, Li Haozhou, Harmsen Michiel, Sun Shiqi, Wang Xiangxi, Guo Huichen

机构信息

State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

出版信息

Protein Cell. 2022 Jun;13(6):446-453. doi: 10.1007/s13238-021-00828-9. Epub 2021 Feb 18.

DOI:10.1007/s13238-021-00828-9
PMID:33599962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9095805/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b66/9095805/2e518a54e351/13238_2021_828_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b66/9095805/afe5845c011c/13238_2021_828_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b66/9095805/2e518a54e351/13238_2021_828_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b66/9095805/afe5845c011c/13238_2021_828_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b66/9095805/2e518a54e351/13238_2021_828_Fig2_HTML.jpg

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Science. 2019 Nov 1;366(6465):640-644. doi: 10.1126/science.aaz1439. Epub 2019 Oct 17.
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Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71.两种针对人类肠道病毒 71 的高效抗体的中和机制。
mBio. 2018 Jul 3;9(4):e01013-18. doi: 10.1128/mBio.01013-18.
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Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies.两种强效治疗性抗体中和日本脑炎病毒的结构基础。
通过定点竞争酶联免疫吸附测定法检测中和抗体，重新绘制O型口蹄疫病毒不同拓扑型衣壳上中和位点的空间分布及其免疫显性。
Microbiol Spectr. 2025 Jun 3;13(6):e0334424. doi: 10.1128/spectrum.03344-24. Epub 2025 May 15.
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Evaluation of the immune effect of foot-and-mouth disease virus-like particles derived from on mice and pigs.源自[具体来源未给出]的口蹄疫病毒样颗粒对小鼠和猪免疫效果的评估。
Front Microbiol. 2025 Apr 14;16:1551395. doi: 10.3389/fmicb.2025.1551395. eCollection 2025.
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A neutralizing nanobody-based liquid-phase blocking ELISA to assess the protective potency of Senecavirus A vaccine.一种基于中和纳米抗体的液相阻断ELISA法，用于评估A组赛尼卡病毒疫苗的保护效力。
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