Indian Veterinary Research Institute, Hebbal, Bangalore 560 024, India.
University of Agricultural Sciences, Dharwad 580 005, India.
Vet Microbiol. 2014 Mar 14;169(3-4):233-5. doi: 10.1016/j.vetmic.2014.01.005. Epub 2014 Jan 18.
The presence of maternal antibodies is a major obstacle for eliciting protective immune responses to foot-and-mouth disease (FMD) vaccines in young, growing animals. In this report, we analyzed the ability of inactivated quadrivalent oil emulsified and aluminium hydroxide adjuvanted FMD vaccines to elicit neutralizing antibody responses in growing calves that had maternal antibodies. Our results demonstrate that oil emulsified vaccines but not aluminium hydroxide adjuvanted FMD vaccines could surmount maternal antibodies to elicit strong and significant levels of neutralizing antibody responses in growing claves.
母源抗体的存在是在幼小动物中引发针对口蹄疫（FMD）疫苗的保护性免疫应答的主要障碍。在本报告中，我们分析了已免疫母源抗体的生长小牛中，使用四价灭活油乳剂和氢氧化铝佐剂的 FMD 疫苗引发中和抗体应答的能力。我们的结果表明，油乳剂疫苗但不是氢氧化铝佐剂的 FMD 疫苗能够克服母源抗体，在生长小牛中引发强烈且显著水平的中和抗体应答。
