School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
J Nat Prod. 2021 Apr 23;84(4):1226-1231. doi: 10.1021/acs.jnatprod.0c01296. Epub 2021 Feb 18.
Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new -terphenyl derivatives, namely, nocarterphenyls D-H (-), were obtained and characterized from the cultures of the marine sediment-derived actinomycete sp. HDN154086. The skeleton of nocarterphenyl D () was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E-H (-) are -terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 μM, and exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.
在 MS/MS 基分子网络和 X 射线衍射分析的辅助下，从海洋沉积物来源的放线菌 sp. HDN154086 的培养物中获得并鉴定了五个新的三联苯衍生物，即 nocarterphenyls D-H(-)。 nocarterphenyl D()的骨架被定义为具有罕见的 2,2'-联噻唑支架，这是首次在自然界中发现，而 nocarterphenyls E-H(-)则是具有不寻常硫醚连接脂肪酸甲酯取代基的三联苯醌。化合物 对多种细菌表现出有希望的活性，MIC 值范围为 1.5 至 6.2 μM，并且对 MRSA 表现出显著的抗菌活性，超过了阳性对照环丙沙星。
