来自绿僵菌属虫草定殖分离株的生物活性对三联苯衍生物

Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp.

作者信息

Guo Huijuan, Hu Hejiao, Liu Shuchun, Liu Xingzhong, Zhou Yuguang, Che Yongsheng

机构信息

Key Laboratory of Systemic Mycology and Lichenology, Center for Bio-Energy and Industrial Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.

出版信息

J Nat Prod. 2007 Sep;70(9):1519-21. doi: 10.1021/np070231k. Epub 2007 Sep 14.

DOI:10.1021/np070231k

PMID:17854154

Abstract

Gliocladinins A (1) and B (2), two new p-terphenyl derivatives, have been isolated from solid cultures of an isolate of Gliocladium sp. that colonizes Cordyceps sinensis. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. In standard disk assays, compounds 1 and 2 showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538). In addition, these compounds displayed inhibitory effects on the growth of two human tumor cell lines, HeLa and HCT116.

摘要

从一株定殖于冬虫夏草的粘帚霉属菌株的固体培养物中分离得到了两种新的对三联苯衍生物——粘帚菌素A（1）和B（2）。这些化合物的结构主要通过对其核磁共振光谱数据的分析来确定。在标准滤纸片法试验中，化合物1和2对金黄色葡萄球菌（ATCC 6538）表现出中等程度的抗菌活性。此外，这些化合物对两种人类肿瘤细胞系HeLa和HCT116的生长具有抑制作用。