Ameratunga R, Harris E A
Clinical Physiology Department, Green Lane Hospital, Auckland, New Zealand.
Eur Respir J. 1988 Feb;1(2):115-8.
The measurement and interpretation of "diffusing capacity" by either single-breath or steady-state methods are complicated by both technical and conceptual difficulties. The CO uptake fraction is less complex but, as originally described, it is unacceptably sensitive to dead-space ventilation. A modification (the "alveolar CO uptake fraction", UA) largely removes this factor. We have measured UA in thirteen healthy subjects and 100 patients with a variety of pulmonary disorders. It is reproducible and appears sensitive to clinical abnormality. Its technical and interpretative simplicity suggest its use as an alternative to other measures of CO transfer.
通过单次呼吸或稳态方法测量和解释“弥散能力”会受到技术和概念上的双重困难的影响。一氧化碳摄取分数没那么复杂,但按照最初的描述,它对死腔通气过于敏感,令人难以接受。一种改进方法(“肺泡一氧化碳摄取分数”,UA)在很大程度上消除了这个因素。我们已经对13名健康受试者和100名患有各种肺部疾病的患者测量了UA。它具有可重复性,并且似乎对临床异常情况敏感。其技术和解释的简易性表明它可用作一氧化碳转移其他测量方法的替代方法。