Zherdev V P, Sariev A K, Voronina T A, Kliuev N A, Smirnov L D
Farmakol Toksikol. 1988 Jan-Feb;51(1):55-9.
Study of biotransformation of 2-ethyl-6-methyl-3-hydroxypyridine (2E6M3O) in rats by using high performance liquid chromatography and mass spectrometry resulted in isolation and identification of its 5 metabolites represented by dealkylated and conjugated products of transformation. In terms of manifestation of the pharmacological effect of 2E3M3O, of interest may be the identified metabolite 2E6M3O-phosphate which was found in considerable amounts in the livers of the animals. All the rest metabolites were detected only in the rat urine.
利用高效液相色谱法和质谱法对大鼠体内2-乙基-6-甲基-3-羟基吡啶（2E6M3O）的生物转化进行研究，结果分离并鉴定出其5种代谢产物，这些代谢产物以转化的脱烷基化产物和共轭产物为代表。就2E3M3O药理作用的表现而言，所鉴定出的代谢产物2E6M3O-磷酸盐可能值得关注，在动物肝脏中发现其含量可观。其余所有代谢产物仅在大鼠尿液中检测到。
