Guo L W, Zhang S K, Liu S Z, Zheng L Y, Chen Q, Cao X Q, Sun X B, Zhang J G
Henan Office for Cancer Control and Research, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
Zhonghua Zhong Liu Za Zhi. 2021 Feb 23;43(2):233-237. doi: 10.3760/cma.j.cn112152-20200331-00286.
To evaluate the compliance rate and its impact factors of liver cancer screening for high-risk groups in urban areas of Henan Province from 2013 to 2019. Residents of 40-74 years old in 8 cities of Henan province were selected to investigate the risk factors and liver cancer risk assessment. Subjects with high risk of liver cancer received AFP combined ultrasonography for screening. Chi-square tests were used to compare the differences in liver cancer screening participation rates between groups. Multivariate logistic regression models were applied to explore the potential factors correlating to the compliance of liver cancer screening. Overall, 3 6781 participants who met the inclusion criteria were included in this analysis, and 17 241 of them took the following liver cancer screening, yielding a participation rate of 46.87%. The participation rate varied greatly across cities, ranging from 62.50% to 38.59%. Moreover, the participation rate varied greatly across periods, ranging from 52.77% in 2014-2015 to 38.14% in 2013-2014. The multivariate Logistic regression analyses showed that: female, older, high education degree, cigarette and alcohol intake, infrequent physical exercise, chronic hepatitis B, chronic hepatitis C, fatty liver, gallstones and a family history of liver cancer were inclined to accept liver cancer screening (<0.05). The overall participation rate of liver cancer screening among high-risk population is less than 50% in urban areas of Henan Province. Implement of effective interventions targeting the specific high-risk populations might improve the overall compliance rate of liver cancer screening in the future.
评估2013年至2019年河南省城市地区高危人群肝癌筛查的依从率及其影响因素。选取河南省8个城市40 - 74岁的居民，调查其危险因素及肝癌风险评估情况。肝癌高危受试者接受甲胎蛋白联合超声检查进行筛查。采用卡方检验比较各组肝癌筛查参与率的差异。应用多因素logistic回归模型探讨与肝癌筛查依从性相关的潜在因素。总体而言，本分析纳入了36781名符合纳入标准的参与者，其中17241人进行了后续的肝癌筛查，参与率为46.87%。各城市的参与率差异很大，从62.50%到38.59%不等。此外，不同时期的参与率差异也很大，从2014 - 2015年的52.77%到2013 - 2014年的38.14%不等。多因素logistic回归分析显示：女性、年龄较大、文化程度高、吸烟饮酒、缺乏体育锻炼、慢性乙型肝炎、慢性丙型肝炎、脂肪肝、胆结石及肝癌家族史者更倾向于接受肝癌筛查（P<0.05）。河南省城市地区高危人群肝癌筛查的总体参与率不到50%。针对特定高危人群实施有效的干预措施可能会提高未来肝癌筛查的总体依从率。
