手术方式对伴后纵韧带骨化症的退行性颈椎脊髓病患者治疗效果有何影响?一项倾向评分匹配的多中心住院患者及出院后90天结局分析
What Is the Impact of Surgical Approach in the Treatment of Degenerative Cervical Myelopathy in Patients With OPLL? A Propensity-Score Matched, Multi-Center Analysis on Inpatient and Post-Discharge 90-Day Outcomes.
作者信息
Lee Nathan J, Boddapati Venkat, Mathew Justin, Fields Michael, Vulapalli Meghana, Kim Jun S, Lombardi Joseph M, Sardar Zeeshan M, Lehman Ronald A, Riew K Daniel
机构信息
Department of Orthopaedics, Columbia University Medical Center, The Och Spine Hospital at New York-Presbyterian, New York, NY, USA.
出版信息
Global Spine J. 2023 Mar;13(2):324-333. doi: 10.1177/2192568221994797. Epub 2021 Feb 19.
STUDY DESIGN
Retrospective cohort.
OBJECTIVE
Provide a comparison of surgical approach in the treatment of degenerative cervical myelopathy in patients with OPLL.
METHODS
A national database was queried to identify adult (≥18 years) patients with OPLL, who underwent at least a 2-level cervical decompression and fusion for cervical myelopathy from 2012-2014. A propensity-score-matching algorithm was employed to compare outcomes by surgical approach.
RESULTS
After propensity-score matching, 627 patients remained. An anterior approach was found to be an independent predictor for higher inpatient surgical complications(OR 5.9), which included dysphagia:14%[anterior]vs.1.1%[posterior] -value < 0.001, wound hematoma:1.7%[anterior]vs.0%[posterior] -value = 0.02, and dural tear:9.4%[anterior]vs.3.2%[posterior] -value = 0.001. A posterior approach was an predictor for longer hospital length of stay by nearly 3 days(OR 3.4; 6.8 days[posterior]vs.4.0 days[anterior] -value < 0.001). The reasons for readmission/reoperation did not vary by approach for 2-3-level fusions; however, for >3-level fusions, patients with an anterior approach more often had respiratory complications requiring mechanical ventilation(-value = 0.038) and required revision fusion surgery(-value = 0.015).
CONCLUSIONS
The national estimates for inpatient complications(25%), readmissions(9.9%), and reoperations(3.5%) are substantial after the surgical treatment of multi-level OPLL. An anterior approach resulted in significantly higher inpatient surgical complications, but this did not result in a longer hospital length of stay and the overall 90-day complication rates requiring readmission or reoperation was similar to those seen after a posterior approach. For patients requiring >3-level fusion, an anterior approach is associated with significantly higher risk for respiratory complications requiring mechanical ventilation and revision fusion surgery. Precise neurological complications and functional outcomes were not included in this database, and should be further assessed in future studies.
研究设计
回顾性队列研究。
目的
比较手术方式治疗伴后纵韧带骨化(OPLL)的退行性颈椎脊髓病患者的疗效。
方法
查询国家数据库,确定2012年至2014年期间接受至少两节段颈椎减压融合术治疗颈椎脊髓病的成年(≥18岁)OPLL患者。采用倾向评分匹配算法比较不同手术方式的疗效。
结果
倾向评分匹配后,剩余627例患者。发现前路手术是住院手术并发症较高的独立预测因素(比值比5.9),其中包括吞咽困难:14%[前路]对1.1%[后路] - P值<0.001,伤口血肿:1.7%[前路]对0%[后路] - P值 = 0.02,以及硬脊膜撕裂:9.4%[前路]对3.2%[后路] - P值 = 0.001。后路手术是住院时间延长近3天的预测因素(比值比3.4;6.8天[后路]对4.0天[前路] - P值<0.001)。2 - 3节段融合的再入院/再次手术原因不因手术方式而异;然而,对于>3节段融合,前路手术患者更常出现需要机械通气的呼吸并发症(P值 = 0.038),并需要翻修融合手术(P值 = 0.015)。
结论
多节段OPLL手术治疗后,全国范围内住院并发症(25%)、再入院(9.9%)和再次手术(3.5%)的发生率较高。前路手术导致住院手术并发症显著增加,但这并未导致住院时间延长,且需要再入院或再次手术的总体90天并发症发生率与后路手术后相似。对于需要>3节段融合的患者,前路手术与需要机械通气的呼吸并发症和翻修融合手术的风险显著增加相关。该数据库未包括精确的神经并发症和功能结果,未来研究应进一步评估。