Considering the importance of COVID-19 disease pandemic, emerged by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in line with other studies to find appropriate prevention or treatment methods for this virus infection, our study objective was proposing the use of natural derived ingredients as an approach for COVID-19 disease control. Here we reviewed previous studies on natural derived nasal sprays andfound that some known natural derived ingredients have antiviral properties, so their topical use as a nasalspray is effective in reducing the symptoms of respiratory infections. Moreover, such nasal sprays also have thepotential of decreasing viral load, including titer of coronaviruses, in the nasal cavity. It seems that the use ofcarrageenan or other herbal ingredients in the nasal spray may block the SARS-CoV-2 virus from entering thelung cells of an affected person and can also prevent virus transmission to other susceptible persons. Further,noticing what we know about the novel 2019 coronavirus so far, we suggested carrageenan that has an unspecific physical antiviral activity and some other natural derived ingredients, as a choice in coping with SARS-CoV-2 virus infection.