一氧化氮鼻喷剂（NONS）治疗轻度 COVID-19 感染的临床疗效。

Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection.

机构信息

Consultant Medical Virologist, Frimley Health NHS Foundation Trust, Portsmouth Road, Camberley, Surrey GU16 7UJ, United Kingdom.

Medical Student, University of Cambridge School of Clinical Medicine, Box 111 Cambridge Biomedical Campus, Cambridge CB2 0SP, United Kingdom.

出版信息

J Infect. 2021 Aug;83(2):237-279. doi: 10.1016/j.jinf.2021.05.009. Epub 2021 May 13.

DOI:10.1016/j.jinf.2021.05.009

PMID:33992687

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117664/

Abstract

Baek et al. investigated the duration of COVID-19 virus shedding in infected patients and demonstrated that even in patients demonstrating prolonged viral clearance, the virus was no longer viable after 15 days post onset of symptoms. Our study aimed to measure whether nitric oxide nasal spray (NONS) further accelerates this reduction in SARS-CoV-2 RNA load versus a control arm with saline spray. Our study recruited 80 participants who were divided into a NONS treatment arm or a placebo arm to test the efficacy of NONS as a treatment for mild COVID-19 infection.

摘要

贝克等人研究了感染患者体内 COVID-19 病毒的脱落时间，结果表明，即使在病毒清除时间延长的患者中，症状出现 15 天后病毒也不再具有活性。我们的研究旨在测量与生理盐水喷雾的对照组相比，一氧化氮鼻腔喷雾（NONS）是否进一步加速 SARS-CoV-2 RNA 载量的降低。我们的研究招募了 80 名参与者，他们被分为 NONS 治疗组或安慰剂组，以测试 NONS 作为轻度 COVID-19 感染治疗的效果。