Department of Periodontology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, China.
BMC Oral Health. 2021 Feb 18;21(1):79. doi: 10.1186/s12903-021-01418-1.
(-)-Epigallocatechin Gallate (EGCG) as green tea catechins possessed antibacterial and anti-inflammatory effects on periodontal disease. This study was designed to evaluate the clinical and microbiological efficacy of scaling and root planing (SRP) using EGCG aqueous solution as coolants through a new-type ultrasonic scaler tip on chronic periodontitis.
This split-mouth, randomized clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and the maxillary contra-lateral sides were allocated into test and control groups randomly. Through the new-type scaler tip, 762 sites with probing depth (PD) ≥ 4 mm were treated by SRP using EGCG solution or distilled water as coolants respectively. Clinical parameters and red complex pathogens in subgingival microbiome were evaluated at baseline, 3 and 6 months after treatments.
During 6 months, the SRP plus EGCG medication contributed to additional PD reduction as 0.33 mm and gain of clinical attachment level as 0.3 mm compared with SRP alone, and approximate 8% more sites obtained PD reduction ≥ 2 mm (p < 0.05). Meanwhile, the mean relative abundance of Tannerella forsythia was significantly lower in the combined treatment group (p < 0.05).
The purified EGCG showed the potential to improve the outcome of periodontal non-surgical treatment and the new-type scaler tip provided an alternative vehicle for subgingival medication. Trial registration The trial was registered in Chinese Clinical Trial Registry on 15 February 2020 (No.: ChiCTR2000029831, retrospectively registered). http://www.chictr.org.cn/showprojen.aspx?proj=49441 .
（-）-表没食子儿茶素没食子酸酯（EGCG）作为绿茶儿茶素对牙周病具有抗菌和抗炎作用。本研究旨在评估使用 EGCG 水溶液作为冷却剂通过新型超声洁牙机尖对慢性牙周炎进行龈下刮治和根面平整（SRP）的临床和微生物疗效。
这项分侧、随机临床试验纳入了 20 名（2 名脱落）慢性牙周炎患者，将上颌对侧分为试验组和对照组。通过新型洁牙机尖，分别使用 EGCG 溶液或蒸馏水作为冷却剂对 762 个探诊深度（PD）≥4mm 的位点进行 SRP 治疗。在基线、治疗后 3 个月和 6 个月时评估临床参数和龈下微生物群中的红色复合体病原体。
在 6 个月期间，与单独的 SRP 相比，SRP 加 EGCG 治疗可使 PD 进一步减少 0.33mm，临床附着水平增加 0.3mm，且约有 8%更多的位点 PD 减少≥2mm（p<0.05）。同时，联合治疗组中 Tannerella forsythia 的平均相对丰度显著降低（p<0.05）。
纯化的 EGCG 显示出改善牙周非手术治疗效果的潜力，新型洁牙机尖为龈下给药提供了另一种载体。
该试验于 2020 年 2 月 15 日在中国临床试验注册中心注册（注册号：ChiCTR2000029831，回顾性注册）。http://www.chictr.org.cn/showprojen.aspx?proj=49441。
