Li Yizhen, Cheng Lei, Li Mingyun
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Pathogens. 2024 Jul 29;13(8):634. doi: 10.3390/pathogens13080634.
Oral diseases are among the most prevalent diseases globally. Accumulating new evidence suggests considerable benefits of epigallocatechin-3-gallate (EGCG) for oral health. This review aims to explore the role and application of EGCG in main oral diseases.
This narrative review thoroughly examines and summarizes the most recent literature available in scientific databases (PubMed, Web of Science, Scopus, and Google Scholar) reporting advances in the role and application of EGCG within the dental field. The major keywords used included "EGCG", "green tea extract", "oral health", "caries", "pulpitis", "periapical disease", "periodontal disease", "oral mucosa", "salivary gland", and "oral cancer".
EGCG prevents and manages various oral diseases through its antibacterial, anti-inflammatory, antioxidant, and antitumor properties. Compared to traditional treatments, EGCG generally exhibits lower tissue irritation and positive synergistic effects when combined with other therapies. Novel delivery systems or chemical modifications can significantly enhance EGCG's bioavailability, prolong its action, and reduce toxicity, which are current hotspots in developing new materials.
this review provides an exhaustive overview of the biological activities of EGCG to major oral diseases, alongside an exploration of applications and limitations, which serves as a reference for preventing and managing oral ailments.
口腔疾病是全球最普遍的疾病之一。越来越多的新证据表明，表没食子儿茶素没食子酸酯（EGCG）对口腔健康有诸多益处。本综述旨在探讨EGCG在主要口腔疾病中的作用及应用。
本叙述性综述全面检索并总结了科学数据库（PubMed、科学网、Scopus和谷歌学术）中关于EGCG在牙科领域作用及应用进展的最新文献。使用的主要关键词包括“EGCG”、“绿茶提取物”、“口腔健康”、“龋齿”、“牙髓炎”、“根尖周病”、“牙周病”、“口腔黏膜”、“唾液腺”和“口腔癌”。
EGCG通过其抗菌、抗炎、抗氧化和抗肿瘤特性预防和管理各种口腔疾病。与传统治疗方法相比，EGCG通常表现出较低的组织刺激性，并且与其他疗法联合使用时具有积极的协同作用。新型给药系统或化学修饰可显著提高EGCG的生物利用度，延长其作用时间并降低毒性，这些是开发新材料的当前热点。
本综述全面概述了EGCG对主要口腔疾病的生物学活性，并探讨了其应用和局限性，为预防和管理口腔疾病提供参考。
