工作效率低下与慢性阻塞性肺疾病患者的运动能力差和健康相关生活质量差有关。
Poor Work Efficiency is Associated with Poor Exercise Capacity and Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease.
机构信息
Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan.
Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
出版信息
Int J Chron Obstruct Pulmon Dis. 2021 Feb 10;16:245-256. doi: 10.2147/COPD.S283005. eCollection 2021.
INTRODUCTION
Chronic obstructive pulmonary disease (COPD) is a progressive disease with deteriorating cardiopulmonary function that decreases the health-related quality of life (HRQL) and exercise capacity. Patients with COPD often have cardiovascular and muscular problems that hinder oxygen uptake by peripheral tissues, resulting in poor oxygen consumption efficiency. It is important to develop new physiological parameters to evaluate oxygen consumption efficiency during activities and to evaluate its association with exercise capacity and HRQL. Work efficiency (WE) measures oxygen consumption efficiency during exercise. We hypothesize that patients with poor WE should have exercise intolerance and poor HRQL. Therefore, we aimed to evaluate the association between WE and exercise capacity, HRQL and other cardiopulmonary parameters.
PATIENTS AND METHODS
Seventy-eight patients with COPD were evaluated with spirometry, cardiopulmonary exercise testing, and assessment of dyspnea score and HRQL (using the St. George's Respiratory Questionnaire [SGRQ]). Cardiopulmonary exercise testing was performed using a cycle ergometer with an incremental protocol and exhaled breath analysis to assess oxygen consumption. WE was defined as the relationship between oxygen consumption and workload.
RESULTS
There were 31 patients with normal WE (group I) and 47 patients (group II) with poor WE. Patients with poor WE had lower exercise capacity (maximal oxygen consumption, group I vs II as 1050±53 vs 845 ±34 mL/min, p=0.0011), poorer HRQL (SGRQ score 41.1±3.0 vs 55±2.2, p=0.0002), higher exertional dyspnea score (5.1±0.2 vs 6.1±0.2, p= 0.0034) and early anaerobic metabolism during exercise (anaerobic threshold, 672±27 vs 583 ±18 mL/min, p=0.0052).
CONCLUSION
WE is associated with exercise capacity and HRQL. Here, patients with poor WE also had exercise intolerance, poorer HRQL, and more exertional dyspnea.
简介
慢性阻塞性肺疾病（COPD）是一种心肺功能逐渐恶化的进行性疾病，降低了健康相关生活质量（HRQL）和运动能力。COPD 患者通常存在心血管和肌肉问题，这些问题会阻碍外周组织摄取氧气，导致氧气消耗效率低下。开发新的生理参数来评估活动期间的氧气消耗效率并评估其与运动能力和 HRQL 的关系非常重要。工作效率（WE）衡量运动期间的氧气消耗效率。我们假设 WE 差的患者应存在运动不耐受和 HRQL 差的情况。因此，我们旨在评估 WE 与运动能力、HRQL 和其他心肺参数之间的关系。
患者和方法
对 78 例 COPD 患者进行了肺量测定、心肺运动测试、呼吸困难评分和 HRQL（使用圣乔治呼吸问卷[SGRQ]）评估。心肺运动测试使用带有递增方案的脚踏车测力计和呼气分析来评估氧气消耗，定义 WE 为氧气消耗与工作量的关系。
结果
31 例患者 WE 正常（I 组），47 例患者 WE 差（II 组）。WE 差的患者运动能力更低（最大耗氧量，I 组与 II 组分别为 1050±53 与 845±34 mL/min，p=0.0011），HRQL 更差（SGRQ 评分，41.1±3.0 与 55±2.2，p=0.0002），运动时呼吸困难评分更高（5.1±0.2 与 6.1±0.2，p=0.0034），运动时早期发生无氧代谢（无氧阈，672±27 与 583±18 mL/min，p=0.0052）。
结论
WE 与运动能力和 HRQL 相关。在此，WE 差的患者还存在运动不耐受、HRQL 更差和更严重的运动时呼吸困难。
Zotero 插件