Jao Lun-Yu, Hsieh Po-Chun, Wu Yao-Kuang, Tzeng I-Shiang, Yang Mei-Chen, Su Wen-Lin, Lan Chou-Chin
Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Tzu Chi Med J. 2024 Jan 12;36(1):76-82. doi: 10.4103/tcmj.tcmj_171_23. eCollection 2024 Jan-Mar.
Asthma is a chronic respiratory disease that affects millions of people worldwide and causes severe symptoms such as wheezing, coughing, and breathing difficulty. Despite modern treatments, 3%-10% of patients develop severe asthma, which requires high-dose medications, and they may still experience frequent and severe symptoms, exacerbations, and psychological impacts. This study aimed to investigate the effects of high-intensity aerobic exercise training (HIAET) in patients with severe asthma.
Patients with severe asthma were recruited, and cardiopulmonary exercise tests, dyspnea, and leg fatigue scores were performed before HIAET. Participants underwent a 12-week hospital-based HIAET, which involved exercising twice weekly to reach 80% of their peak oxygen uptake (VO).
Eighteen patients with severe asthma underwent HIAET, which resulted in significant improvement in peak VO (1214.0 ± 297.9-1349.4 ± 311.2 mL/min, = 0.004) and work rate (80.6 ± 21.2-96.2 ± 24.8 watt, < 0.001) and decrease in dyspnea (5.1 ± 1.8-4.1 ± 1.2, = 0.017) and fatigue scores (5.2 ± 2.3-4.0 ± 1.2, = 0.020) at peak exercise. No significant changes were observed in spirometry results, respiratory muscle strength, or circulatory parameters.
HIAET can lead to improved exercise capacity and reduced dyspnea and fatigue scores at peak exercise without changes in spirometry, respiratory muscle strength, and circulatory parameters.
哮喘是一种慢性呼吸道疾病，影响着全球数百万人，会引发喘息、咳嗽和呼吸困难等严重症状。尽管有现代治疗方法，但仍有3%-10%的患者发展为重度哮喘，这需要高剂量药物治疗，而且他们可能仍会频繁出现严重症状、病情加重以及受到心理影响。本研究旨在调查高强度有氧运动训练（HIAET）对重度哮喘患者的影响。
招募重度哮喘患者，在进行HIAET之前进行心肺运动测试、呼吸困难和腿部疲劳评分。参与者接受了为期12周的基于医院的HIAET，包括每周锻炼两次，达到其最大摄氧量（VO）的80%。
18名重度哮喘患者接受了HIAET，这导致最大摄氧量（从1214.0±297.9-1349.4±311.2毫升/分钟，P=0.004）和工作率（从80.6±21.2-96.2±24.8瓦，P<0.001）显著改善，运动高峰时呼吸困难评分（从5.1±1.8-4.1±1.2，P=0.017）和疲劳评分（从5.2±2.3-4.0±1.2，P=0.020）降低。肺功能检查结果、呼吸肌力量或循环参数未观察到显著变化。
HIAET可提高运动能力，降低运动高峰时的呼吸困难和疲劳评分，而肺功能检查、呼吸肌力量和循环参数无变化。
