Krzych-Fałta Edyta, Furmańczyk Konrad, Dziewa-Dawidczyk Diana, Wojas Oksana, Retlewska Katarzyna, Samoliński Bolesław K
Unit of Environmental Hazard Prevention and Allergology, Medical University of Warsaw, Warsaw, Poland.
Chair of Applied Mathematics, Faculty of Applied Informatics and Mathematics, Warsaw University of Life Sciences, Warsaw, Poland.
Postepy Dermatol Alergol. 2020 Dec;37(6):890-897. doi: 10.5114/ada.2019.84719. Epub 2019 May 15.
The current state of knowledge is that allergic rhinitis can occur in two forms. One is allergic rhinitis as a manifestation of a systemic allergy with systemic atopy and positive results of skin prick tests or sIgE tests. The other is local allergic rhinitis (LAR) as a local allergic reaction affecting only the nasal mucosa without systemic atopy.
To attempt to assess the usefulness of the nasal allergen provocation test for the purposes of differential diagnosis and the qualification of LAR patients for therapy.
The subjects in the study were a group of 6 adults diagnosed with LAR on the basis of their medical history and the results of nasal allergen provocation tests, with the allergens being house dust mites ( The methods adopted in the study were a point-based rating scale as a measure of nasal/extranasal complaints and active anterior rhinomanometry.
Significant differences ( < 0.05) were observed, using the subjective rating scale, in relation to registered nasal and extranasal complaints in the early phase of the allergic reaction. Similarly, the rhinomanometry method revealed significant differences in nasal resistance values before and after the administration of an allergen.
The nasal allergen provocation test is the only testing tool that objectively measures the degree of the patient's allergic reactions and is useful in qualifying LAR patients for further therapy.
目前的知识状况是，变应性鼻炎可表现为两种形式。一种是作为全身性过敏表现的变应性鼻炎，伴有全身性特应性，皮肤点刺试验或特异性免疫球蛋白E（sIgE）检测结果呈阳性。另一种是局部变应性鼻炎（LAR），作为仅影响鼻黏膜而无全身性特应性的局部过敏反应。
试图评估鼻过敏原激发试验在鉴别诊断以及LAR患者治疗资格判定方面的实用性。
本研究的受试者为一组6名成年人，他们根据病史和鼻过敏原激发试验结果被诊断为LAR，过敏原为屋尘螨。本研究采用的方法是基于点数的评分量表作为衡量鼻内/鼻外症状的指标，以及主动前鼻测压法。
使用主观评分量表观察到，在过敏反应早期记录的鼻内和鼻外症状方面存在显著差异（P<0.05）。同样，鼻测压法显示在给予过敏原前后鼻阻力值存在显著差异。
鼻过敏原激发试验是唯一能客观测量患者过敏反应程度的检测工具，有助于确定LAR患者是否适合进一步治疗。
