Ghanbari Zinat, Sohbati Samira, Eftekhar Tahereh, Sahebi Leyla, Darvish Soodabeh, Alasiri Safa, Deldar Pasikhani Marayam
Department of Obstetrics & Gynecology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics & Gynecology, Kerman University of Medical Sciences, Kerman, Iran.
J Family Reprod Health. 2020 Jun;14(2):68-73. doi: 10.18502/jfrh.v14i2.4347.
The aim of this study was to evaluate the safety and efficacy of fractional CO2 laser for treatment of vulvovaginal atrophy. In this clinical trial study, we evaluated the laser effect on vulvovaginal atrophy in 47 women aged 43-80 years. Each woman was treated with fractional CO2 laser, SmartXide2V2LR, DEKA, Monalisa Touch, vaginal 360o probe and cosmetic probe. The severity of vulvovaginal atrophy symptoms was evaluated before first session of laser and every 4 weeks after laser treatment until 12 weeks. Adverse effects including pain and itching were assessed at all visits. The statistical analysis was performed using SPSS version 23. The response to laser therapy for vaginal dryness was significantly (p <0.001) improved. Also, the response to laser therapy for each symptom include dyspareunia, vaginal discharge, itching and urge urinary incontinence was statistically significant (p <0.001) based on visual analogue scale (VAS). It seems vaginal fractional CO2 laser can be applied as an effective and safe treatment method in genitourinary syndrome of menopause (GSM). It is necessary to conduct studies with long-term follow-up.
本研究的目的是评估二氧化碳点阵激光治疗外阴阴道萎缩的安全性和有效性。在这项临床试验研究中，我们评估了47名年龄在43至80岁之间的女性二氧化碳点阵激光对外阴阴道萎缩的疗效。每位女性均接受了二氧化碳点阵激光（SmartXide2V2LR，DEKA，Monalisa Touch）、阴道360°探头和美容探头的治疗。在首次激光治疗前以及激光治疗后每4周直至12周，对外阴阴道萎缩症状的严重程度进行评估。在每次就诊时评估包括疼痛和瘙痒在内的不良反应。使用SPSS 23版进行统计分析。激光治疗对阴道干涩的反应有显著改善（p<0.001）。此外，根据视觉模拟量表（VAS），激光治疗对性交困难、阴道分泌物、瘙痒和急迫性尿失禁等每种症状的反应均具有统计学意义（p<0.001）。看来阴道二氧化碳点阵激光可作为绝经后泌尿生殖综合征（GSM）的一种有效且安全的治疗方法。有必要进行长期随访研究。
