Manciuc Carmen, Nemescu Dragos, Vata Andrei, Lacatusu Georgiana Alexandra
Department of Infectious Diseases, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.
Exp Ther Med. 2021 Mar;21(3):279. doi: 10.3892/etm.2021.9710. Epub 2021 Jan 25.
As it spread globally, the new SARS-CoV-2 virus was first confirmed in Romania in February 2020, inevitably infecting individuals with diabetes mellitus (DM) along the way. Diabetes is known to affect the response of the body to pathogens and, according to studies conducted in the last 3 months, it appears that diabetic patients are at a higher risk for developing severe forms of the disease and multiple complications. We performed a retrospective study in order to assess the patients with SARS-CoV-2 infection and DM admitted to 'Sf. Parascheva' Clinical Hospital of Infectious Diseases from March 4th until June 30th, 2020. Of the total 1,080 patients admitted during this period, 85 patients (7.87%) had underlying DM, mostly type 2 (82 cases, 96.46%); the mean age of these patients was 62, and 42 were men (49.41%). Chest CTs revealed indicative SARS-CoV-2 images for all patients and their treatment included individually tailored administration of hydroxychloroquine/lopinavir + ritonavir/enoxaparin sodium/tocilizumab/antibiotherapy according to the then national and international guidelines. In total, 70 patients (82.35%) were cured and 15 succumbed to MODS and/or associated neoplasia, bringing the fatality rate to 17.64%. Although advanced age and DM have been associated with aggravated forms of SARS-CoV-2 infection, over 80% of the patients included in the present study were cured. Nonetheless, diabetes appears to be a significant predictor of morbidity and mortality in the SARS-CoV-2 infection.
随着新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在全球传播，2020年2月罗马尼亚首次确诊该病毒，在此过程中不可避免地感染了糖尿病患者。众所周知，糖尿病会影响人体对病原体的反应，根据过去3个月进行的研究，糖尿病患者似乎更易发展为重症疾病并出现多种并发症。我们进行了一项回顾性研究，以评估2020年3月4日至6月30日入住“圣帕拉斯凯瓦”传染病临床医院的SARS-CoV-2感染合并糖尿病患者。在此期间收治的1080例患者中，85例（7.87%）患有基础糖尿病，多数为2型糖尿病（82例，96.46%）；这些患者的平均年龄为62岁，男性42例（49.41%）。胸部CT显示所有患者均有SARS-CoV-2感染的典型影像，其治疗包括根据当时的国家和国际指南，个体化给予羟氯喹/洛匹那韦+利托那韦/依诺肝素钠/托珠单抗/抗生素治疗。共有70例（82.35%）患者治愈，15例死于多器官功能障碍综合征（MODS）和/或相关肿瘤，病死率为17.64%。虽然高龄和糖尿病与SARS-CoV-2感染的加重形式有关，但本研究中超过80%的患者被治愈。尽管如此，糖尿病似乎是SARS-CoV-2感染发病和死亡的重要预测因素。
