Luca Mihaela Cătălina, Loghin Isabela Ioana, Mihai Ioana Florina, Popa Radu, Vâţă Andrei, Manciuc Carmen
Department of Infectious Diseases, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Infectious Diseases, "St. Parascheva" Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania.
J Pers Med. 2023 Feb 17;13(2):349. doi: 10.3390/jpm13020349.
(1) Introduction: While the primary impairment in COVID-19 is pulmonary, the ubiquitous distribution of angiotensin-converting enzyme 2 (ACE2) demonstrates the possible presence of systemic disease with involvement of the heart, kidneys, liver and other organs. (2) Methods: We retrospectively studied the observation sheets of patients diagnosed with SARS-CoV-2 infection hospitalized in the "Sf. Parascheva" Clinical Hospital of Infectious Diseases from Iasi for a period of 3 months. The aim of the study was to identify the frequency of liver injury due to SARS-CoV-2 infection among patients and its impact on the course of the disease. (3) Results: Out of the total number of hospitalized cases (1552), 207 (13.34%) were the subjects of our analysis. The severe form of SARS-CoV-2 infection predominated (108 cases; 52.17%) and in terms of liver damage, in all cases increased transaminase levels predominated and were determined to be secondary to the viral infection. We divided the lot into two groups, A (23 cases; 23.19%) and B (159 cases; 76.81%), depending on the time of onset of liver dysfunction, either at the time of hospitalization or during hospitalization. The evolution of liver dysfunction was predominant in most cases, with an average time of onset at 12.4 days of hospitalization. Death occurred in 50 cases. (4) Conclusions: This study revealed that high AST and ALT at hospital admission was associated with a high mortality risk in COVID-19 patients. Therefore, abnormal liver test results can be a significant prognostic indicator of outcomes in COVID-19 patients.
(1) 引言：虽然新冠病毒病的主要损害在肺部，但血管紧张素转换酶2（ACE2）的广泛分布表明可能存在累及心脏、肾脏、肝脏和其他器官的全身性疾病。(2) 方法：我们回顾性研究了在雅西“圣帕拉谢瓦”传染病临床医院住院3个月的确诊感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）患者的观察记录。本研究的目的是确定患者中因SARS-CoV-2感染导致肝损伤的频率及其对疾病进程的影响。(3) 结果：在全部住院病例（1552例）中，207例（13.34%）为我们的分析对象。SARS-CoV-2感染的重症形式占主导（108例；52.17%），就肝损伤而言，所有病例中转氨酶水平升高占主导，且被确定为继发于病毒感染。根据肝功能障碍出现的时间，即入院时或住院期间，我们将这批患者分为两组，A组（23例；23.19%）和B组（159例；76.81%）。大多数情况下肝功能障碍呈进展性，平均发病时间为住院12.4天。50例患者死亡。(4) 结论：本研究表明，新冠病毒病患者入院时天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）升高与高死亡风险相关。因此，肝功能检查结果异常可能是新冠病毒病患者预后的重要指标。
