Han Ma Ai Thanda, Yu Qi, Tafesh Zaid, Pyrsopoulos Nikolaos
Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
J Clin Transl Hepatol. 2021 Feb 28;9(1):71-80. doi: 10.14218/JCTH.2020.00082. Epub 2020 Dec 14.
Globally, the rise in prevalence of obesity and metabolic syndrome as a whole has been linked to increased access to processed foods, such as refined sugars and saturated fats. Consequently, nonalcoholic fatty liver disease (NAFLD) is on the rise in both developed and developing nations. However, much is still unknown on the NAFLD phenotype with regards to the effect of ethnic diversity. Despite similarities in dietary habits, it appears that certain ethnicities are more protected against NAFLD than others. However, manifestations of the same genetic polymorphisms in different groups of people increase those individuals' predisposition to NAFLD. Diets from different regions have been associated with a lower prevalence of NAFLD and have even been linked to regression of hepatic steatosis. Socioeconomic variations amongst different regions of the world also contribute to NAFLD prevalence and associated complications. Thus, a thorough understanding of ethnic variability in NAFLD is essential to tailoring treatment recommendations to patients of different backgrounds.
在全球范围内，肥胖症和代谢综合征总体患病率的上升与食用加工食品（如精制糖和饱和脂肪）的机会增加有关。因此，非酒精性脂肪性肝病（NAFLD）在发达国家和发展中国家都呈上升趋势。然而，关于种族多样性对NAFLD表型的影响，仍有许多未知之处。尽管饮食习惯存在相似之处，但某些种族似乎比其他种族更能抵御NAFLD。然而，相同的基因多态性在不同人群中的表现会增加这些个体患NAFLD的易感性。来自不同地区的饮食与较低的NAFLD患病率相关，甚至与肝脂肪变性的消退有关。世界不同地区的社会经济差异也导致了NAFLD的患病率及相关并发症。因此，全面了解NAFLD中的种族变异性对于为不同背景的患者制定治疗建议至关重要。
