Wang Qiaoling, Chang Binxia, Li Xiaoyan, Zou Zhengsheng
Peking University, 302 Clinical Medical School, Beijing, China.
Diagnosis and Treatment Center for Non-Infectious Liver Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
J Clin Transl Hepatol. 2021 Feb 28;9(1):90-98. doi: 10.14218/JCTH.2020.00104. Epub 2021 Jan 4.
Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease. gene mutations exist in about 8% of the world's population, with the incidence reaching 45% in East Asia. The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde, facilitating the progression of other liver diseases, including non-alcoholic fatty liver diseases, viral hepatitis and hepatocellular carcinoma, through adduct formation and inflammatory responses. In this review, we seek to summarize recent research progress on the correlation between gene polymorphism and multiple liver diseases, with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.
乙醛脱氢酶2（ALDH2）是酒精代谢的关键酶，参与酒精性肝病的细胞机制。该基因突变存在于世界约8%的人口中，在东亚地区发病率高达45%。这些突变会导致酶活性受损和乙醛积累，通过加合物形成和炎症反应促进包括非酒精性脂肪性肝病、病毒性肝炎和肝细胞癌在内的其他肝脏疾病的进展。在本综述中，我们旨在总结该基因多态性与多种肝脏疾病之间相关性的最新研究进展，试图为更好地理解疾病机制和制定策略提供线索。
