ALDH2 rs671 和 CYP2E1 rs2031920 与东亚地区肝细胞癌易感性的关系：一项荟萃分析。
Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis.
机构信息
College of Clinical Medicine, Jilin University, Changchun, China.
Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, China.
出版信息
World J Surg Oncol. 2020 Jan 27;18(1):21. doi: 10.1186/s12957-020-1796-0.
BACKGROUND
Aldehyde dehydrogenase 2 (ALDH2) and cytochrome p450 2E1 (CYP2E1) are important alcohol-metabolizing enzymes. The aim of this meta-analysis was to evaluate the association of ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms with hepatocellular carcinoma (HCC) susceptibility in East Asians.
METHODS
A systematic search strategy was implemented in MEDLINE, PubMed, Scopus, Embase, and China Academic Journals databases. Nineteen case-control studies were selected for inclusion. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through random-effects or fixed-effects models. Subgroup analysis, meta-regression, sensitivity analysis, cumulative meta-analysis, and evaluation of publication bias were performed.
RESULTS
The overall meta-analysis did not find a significant association of ALDH2 rs671 and CYP2E1 rs2031920 genotypes with HCC susceptibility in East Asians. In addition, stratified analysis by country, Hardy-Weinberg equilibrium status, and source of controls also did not identify any association.
CONCLUSION
The ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms are not associated with HCC susceptibility in East Asians.
背景
乙醛脱氢酶 2（ALDH2）和细胞色素 P450 2E1（CYP2E1）是重要的酒精代谢酶。本荟萃分析的目的是评估 ALDH2 rs671 和 CYP2E1 rs2031920 多态性与东亚人群肝细胞癌（HCC）易感性的关系。
方法
我们在 MEDLINE、PubMed、Scopus、Embase 和中国学术期刊全文数据库中实施了系统的检索策略。选择了 19 项病例对照研究进行纳入。通过随机效应或固定效应模型计算汇总优势比（OR）和 95%置信区间（CI）。进行了亚组分析、meta 回归、敏感性分析、累积荟萃分析和发表偏倚评估。
结果
总体荟萃分析未发现 ALDH2 rs671 和 CYP2E1 rs2031920 基因型与东亚人群 HCC 易感性之间存在显著关联。此外，按国家、哈迪-温伯格平衡状态和对照来源进行的分层分析也未发现任何关联。
结论
ALDH2 rs671 和 CYP2E1 rs2031920 多态性与东亚人群 HCC 易感性无关。
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