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血清巨噬细胞抑制因子-1 作为非小细胞肺癌的临床标志物。

Serum macrophage inhibitory cytokine-1 as a clinical marker for non-small cell lung cancer.

机构信息

Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China.

Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

出版信息

J Cell Mol Med. 2021 Mar;25(6):3169-3172. doi: 10.1111/jcmm.16360. Epub 2021 Feb 18.

DOI:10.1111/jcmm.16360
PMID:33605059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7957168/
Abstract

The aim of this study was to investigate the value of serum macrophage inhibitory factor-1 (MIC-1) level in patients with non-small cell lung cancer (NSCLC). Serum samples from 296 patients with NSCLC and 240 healthy controls were collected. The levels of serum MIC-1 were determined by ELISA. The serum MIC-1 levels in NSCLC patients were higher than that of the controls (P <.001). Univariate and multivariate Cox regression analysis showed that serum MIC-1 was an independent prognostic indicator of OS and PFS. Serum MIC-1 is a valuable biomarker for the diagnosis and prognosis of NSCLC.

摘要

本研究旨在探讨血清巨噬细胞抑制因子-1（MIC-1）水平在非小细胞肺癌（NSCLC）患者中的价值。收集了 296 例 NSCLC 患者和 240 例健康对照者的血清样本。通过 ELISA 法测定血清 MIC-1 水平。NSCLC 患者的血清 MIC-1 水平高于对照组（P<.001）。单因素和多因素 Cox 回归分析表明，血清 MIC-1 是 OS 和 PFS 的独立预后指标。血清 MIC-1 是 NSCLC 诊断和预后的有价值的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a572/7957168/23a80cb93aa8/JCMM-25-3169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a572/7957168/fc778495fe49/JCMM-25-3169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a572/7957168/23a80cb93aa8/JCMM-25-3169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a572/7957168/fc778495fe49/JCMM-25-3169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a572/7957168/23a80cb93aa8/JCMM-25-3169-g002.jpg

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