From the Cambridge Centre for Neuropsychiatric Research, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
Carolina Attention Specialists, Greensboro.
J Clin Psychopharmacol. 2022;42(2):146-153. doi: 10.1097/JCP.0000000000001350.
This study investigated the clinical utility of the combined use of objective and subjective measures of attention-deficit/hyperactivity disorder (ADHD) prepharmacological and postpharmacological treatment.
Adults with ADHD (N = 77) completed the Quantified Behavioral Test, self-ratings of ADHD-related symptoms, and quality of life measures pretreatment and posttreatment.
The use of objective and subjective measures of ADHD-related symptoms during initiation and follow-up of pharmacological treatment resulted in significant improvements in quality of life after 6 months. Both objective and subjective measures captured changes in ADHD-related symptoms, with more patients showing clinically relevant treatment effects on objective measures. Convergence rates between objective and subjective measures were low to moderate, and improvements on these measures correlated with increased quality of life.
Objective and subjective measures of ADHD capture important components of the condition. The findings from this study have important implications for clinical practice.
本研究探讨了在药物治疗前和药物治疗后同时使用客观和主观的注意力缺陷多动障碍（ADHD）评估方法的临床实用性。
77 名 ADHD 成人患者在治疗前后完成了量化行为测试、ADHD 相关症状自评和生活质量评估。
在药物治疗开始和随访期间使用 ADHD 相关症状的客观和主观评估方法，在 6 个月后显著改善了生活质量。客观和主观 ADHD 相关症状评估均显示出改善，更多患者在客观评估上显示出具有临床意义的治疗效果。客观和主观评估方法之间的一致性较低，但这些评估方法的改善与生活质量的提高相关。
ADHD 的客观和主观评估方法都捕捉到了该疾病的重要组成部分。本研究结果对临床实践具有重要意义。
