Wu Shanshan, Wang Hui, Wu Datong, Fan Gao-Chao, Tao Yongxin, Kong Yong
Jiangsu Key Laboratory of Advanced Materials and Technology, Changzhou University, Changzhou 213164, China.
Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Qingdao University of Science and Technology, Qingdao 266042, China.
Analyst. 2021 Mar 7;146(5):1612-1619. doi: 10.1039/d1an00119a. Epub 2021 Feb 19.
β-Cyclodextrin (β-CD) modified silver nanoparticles (AgNPs), denoted as β-CD/AgNPs, were prepared by a simple one-pot method. Due to the inherent chirality of β-CD, the developed β-CD/AgNPs exhibited higher affinity toward l-tyrosine (l-Tyr) than d-tyrosine (d-Tyr), leading to serious aggregation of AgNPs in the presence of l-Tyr. Consequently, the l-Tyr induced aggregation of AgNPs can result in signal amplification in the differential pulse voltammograms (DPVs) of l-Tyr, which can be applied for the electrochemical chiral discrimination of the Tyr enantiomers. Other chiral amino acids including tryptophan and phenylalanine can also be successfully discriminated with the β-CD/AgNPs, suggesting high universality of the developed chiral sensor.
β-环糊精（β-CD）修饰的银纳米颗粒（AgNPs），记为β-CD/AgNPs，通过简单的一锅法制备。由于β-CD固有的手性，所制备的β-CD/AgNPs对L-酪氨酸（L-Tyr）的亲和力高于D-酪氨酸（D-Tyr），导致在L-Tyr存在下AgNPs严重聚集。因此，L-Tyr诱导的AgNPs聚集可导致L-Tyr差分脉冲伏安图（DPV）中的信号放大，可用于Tyr对映体的电化学手性识别。包括色氨酸和苯丙氨酸在内的其他手性氨基酸也可以用β-CD/AgNPs成功识别，表明所开发的手性传感器具有高度通用性。
